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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
PPD induced in vitro interferon gamma production is not a reliable correlate of protection against Mycobacterium tuberculosis
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 99, No. 5, Year 2005
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Description
Correlates of protection against tuberculosis are crucial for the evaluation of new vaccine candidates and for the demonstration of their potential efficacy. Such correlates can be proposed on the basis of animal models. In this study, we hypothesized that protection against tuberculosis (TB) induced by bacillus Calmette-Guerin (BCG) correlates with in vitro TB antigen-specific IFN-γ production. BCG vaccination, known to provide effective protection against TB in animals, was used to investigate the use of in vitro IFN-γ production as a marker of BCG-induced protection against TB. Our results show that BCG vaccination does provide substantial protection against challenge with Mycobacterium tuberculosis. However, despite previous compelling evidence that Th1 type immune responses are essential for TB immunity, the magnitude of in vitro purified protein derivative (PPD)-specific IFN-γ production assessed during the course of TB infection did not correlate with protection. This emphasizes the need to identify further correlates of protection, in addition to IFN-γ, to be used as markers of protective immunity against M. tuberculosis and/or to identify M. tuberculosis antigens inducing IFN-γ that correlate with protective immunity. © 2004 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Elias, Daniel
Sweden, Solna
Department of Microbiology, Tumor and Cell Biology
Ethiopia, Addis Ababa
Armauer Hansen Research Institute
Sweden, Solna
Public Health Agency of Sweden
Akuffo, Hannah Opokua
Sweden, Solna
Department of Microbiology, Tumor and Cell Biology
Sweden, Solna
Public Health Agency of Sweden
Britton, Sven F.F.
Sweden, Stockholm
Karolinska Institutet
Statistics
Citations: 93
Authors: 3
Affiliations: 4
Identifiers
Doi:
10.1016/j.trstmh.2004.08.006
ISSN:
00359203
Research Areas
Health System And Policy
Infectious Diseases