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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Immunological impact of an additional early measles vaccine in Gambian children: Responses to a boost at 3 years
Vaccine, Volume 30, No. 15, Year 2012
Notification
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Description
Background: Measles vaccine in early infancy followed by a dose at 9 months of age protects against measles and enhances child survival through non-specific effects. Little is known of immune responses in the short or long term after booster doses. Methods: Infants were randomized to receive measles vaccine at 9 months of age (group 1) or 4 and 9 months of age (group 2). Both groups received a boost at 36 months of age. T-cell effector and memory responses using IFN-γ ELIspot and cytokine assays and antibody titres using a haemagglutination-inhibition assay were compared at various times. Results: Vaccination at 4 months of age elicited antibody and CD4 T-cell mediated immune responses .Two weeks after vaccination at 9 months of age group 2 had much higher antibody titres than group1 infants; cell-mediated effector responses were similar. At 36 months of age group 2 antibody titres exceeded protective levels but were 4-fold lower than group 1; effector and cytokine responses were similar. Re-vaccination resulted in similar rapid and high antibody titres in both groups (median 512); cellular immunity changed little. At 48 months of age group 2 antibody concentrations remained well above protective levels though 2-fold lower than group 1; T-cell memory was readily detectable and similar in both groups. Conclusions: An additional early measles vaccine given to children at 4 months of age induced a predominant CD4 T-cell response at 9 months and rapid development of high antibody concentrations after booster doses. However, antibody decayed faster in these children than in the group given primary vaccination at 9 months of age. Cellular responses after 9 months were generally insignificantly different. © 2012 Elsevier Ltd.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3401374/bin/mmc1.doc
Authors & Co-Authors
Njie-Jobe, Jainaba
Gambia, Banjul
Medical Research Council Laboratories Gambia
Nyamweya, Samuel Matoya
Gambia, Banjul
Medical Research Council Laboratories Gambia
Miles, David J.C.
Gambia, Banjul
Medical Research Council Laboratories Gambia
van der Sande, Marianne A.B.
Netherlands, Bilthoven
Rijksinstituut Voor Volksgezondheid en Milieu
Netherlands, Utrecht
Universiteit Utrecht
Zaman, Syed M.A.
United Kingdom, London
Public Health England
Touray, Ebrima S.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Hossin, Safayet
Gambia, Banjul
Medical Research Council Laboratories Gambia
Adetifa, Jane U.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Palmero, Melba S.
United States, Anchorage
Adventist Community Services
Burl, Sarah
United Kingdom, London
Imperial College London
Jeffries, David J.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Rowland-Jones, Sarah Louise
United Kingdom, Oxford
Mrc Weatherall Institute of Molecular Medicine
Flanagan, Katie L.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Jaye, Assan
Gambia, Banjul
Medical Research Council Laboratories Gambia
Whittle, Hilton C.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Statistics
Citations: 36
Authors: 15
Affiliations: 7
Identifiers
Doi:
10.1016/j.vaccine.2012.01.083
ISSN:
0264410X
e-ISSN:
18732518
Research Areas
Infectious Diseases
Maternal And Child Health