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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Validation of rapid HIV antibody tests in 5 African Countries
Journal of the International Association of Physicians in AIDS Care, Volume 9, No. 3, Year 2010
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Description
The sensitivity and specificity of 3 rapid HIV antibody tests were assessed at 5 clinical trial sites in Africa and 1 site in the United States using a minimum of 100 HIV antibody positive samples and 100 HIV antibody negative samples at each site. The overall sensitivity and specificity for the OraSure OraQuick, Abbott Determine, and Trinity Unigold tests were 99.3%, 99.8%, and 98.5%, respectively, and 99.3%, 99.4%, and 99.5%, respectively. There were no instances at any site in which false-negative or false-positive results were obtained for the same sample on more than 1 rapid test kit. The results of this study provide assurance that for these diverse sites in Africa, the accuracy of these kits is quite good. Given the excellent accuracy, relatively fast turnaround time, and minimal infrastructure required, these rapid tests for HIV antibody provide a very attractive and accurate testing format. © The Author(s) 2010.
Authors & Co-Authors
Piwowar-Manning, Estelle M.
United States, Baltimore
Johns Hopkins University
Tustin, Nancy B.
United States, Philadelphia
The Children's Hospital of Philadelphia
Sikateyo, Physiwell
Zambia, Lusaka
Cidrz
Kamwendo, Deborah D.
Malawi, Lilongwe
Unc Project-malawi
Chipungu, Chifundo
Malawi, Blantyre
Queen Elizabeth Central Hospital Malawi
Maharaj, Rashika
South Africa, Durban
Sa Medical Research Council
Mushanyu, Jabulani
Zimbabwe, Harare
Uz-ucsf Collaborative Program in Women's Health
Richardson, Barbra Ann
United States, Seattle
University of Washington
Hillier, Sharon L.
United States, Pittsburgh
Magee-womens Research Institute
Jackson, J. Brooks
United States, Baltimore
Johns Hopkins University
Statistics
Citations: 39
Authors: 10
Affiliations: 9
Identifiers
Doi:
10.1177/1545109710368151
ISSN:
15451097
e-ISSN:
15570886
Research Areas
Infectious Diseases