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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Long-term outcome in neuroZika: When biological diagnosis matters
Neurology, Volume 92, No. 21, Year 2019
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Description
ObjectiveTo characterize the full spectrum, relative frequency, and prognosis of the neurologic manifestations in Zika virus (ZIKV) postnatal infection.MethodsWe conducted an observational study in consecutive ZIKV-infected patients presenting with neurologic manifestations during the French West Indies 2016 outbreak.ResultsEighty-seven patients, including 6 children, were enrolled. Ninety-five percent of all cases required hospitalization. Guillain-Barré syndrome was the most frequent manifestation (46.0%) followed by encephalitis or encephalomyelitis (20.7%), isolated single or multiple cranial nerve palsies (9.2%), other peripheral manifestations (6.9%), and stroke (1.1%). Fourteen patients (16.1%), including one child, developed a mixed disorder involving both the central and peripheral nervous system. Mechanical ventilation was required in 21 cases, all of whom had ZIKV RNA in at least one biological fluid. Two adult patients died due to neuroZika. Clinical follow-up (median 14 months; interquartile range, 13-17 months) was available for 76 patients. Residual disability (modified Rankin Scale score ≥2) was identified in 19 (25.0%) patients; in 6 cases (7.9%), disability was severe (modified Rankin Scale score ≥4). Among patients with ZIKV RNA detected in one biological fluid, the risk of residual disability or death was higher (odds ratio 9.19; confidence interval 1.12-75.22; p = 0.039).ConclusionsNeuroZika spectrum represents a heterogeneous group of clinical neurologic manifestations. During an outbreak, clinicians should consider neuroZika in patients presenting with cranial nerve palsies and a mixed neurologic disorder. Long-term sequelae are frequent in NeuroZika. ZIKV reverse-transcription PCR status at admission can inform prognosis and should therefore be taken into consideration in the management of hospitalized patients. © 2019 American Academy of Neurology.
Authors & Co-Authors
Lannuzel, Annie
France, Pointe-a-pitre
Université Des Antilles
France, Paris
Inserm
Madec, Yoann
Unknown Affiliation
Najioullah, Fatiha
France, Pointe-a-pitre
Université Des Antilles
Breurec, Sébastien
France, Pointe-a-pitre
Université Des Antilles
Guadeloupe, Pointe-a-pitre
Institut Pasteur de Guadeloupe
Césaire, Raymond
France, Pointe-a-pitre
Université Des Antilles
Lledó, Pierre Marie
France, Paris
Institut Pasteur, Paris
Thiéry, Guillaume
France, Pointe-a-pitre
Université Des Antilles
Cabiè, André Crossed Dsign©
France, Pointe-a-pitre
Université Des Antilles
France, Paris
Chu, Paris
France, Paris
Inserm
Roze, Emmanuel
France, Paris
Inserm
France, Paris
Institut Pasteur, Paris
Statistics
Citations: 22
Authors: 9
Affiliations: 5
Identifiers
Doi:
10.1212/WNL.0000000000007536
ISSN:
00283878
Research Areas
Disability
Infectious Diseases
Maternal And Child Health
Noncommunicable Diseases
Study Design
Cohort Study
Case-Control Study