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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Noninvasive follow-up of simian immunodeficiency virus infection in wild-living nonhabituated western lowland gorillas in Cameroon
Journal of Virology, Volume 86, No. 18, Year 2012
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Description
Simian immunodeficiency viruses infecting western lowland gorillas (SIVgor) are closely related to HIV-1 and are most likely the ancestors of HIV-1 groups O and P. At present, limited data are available on genetic diversity, transmission, viral evolution, and pathogenicity of SIVgor in its natural host. Between 2004 and 2011, 961 putative gorilla fecal samples were collected at the Campo Ma'an National Park, Cameroon. Among them, 16% cross-reacted with HIV-1 antibodies, corresponding to at least 34 infected gorillas. Combining host genotyping and field data, we identified four social groups composed of 7 to 15 individuals each, with SIV rates ranging from 13% to 29%. Eleven SIVgor-infected gorillas were sampled multiple times; two most likely seroconverted during the study period, showing that SIVgor continues to spread. Phylogenetic analysis of partial env and pol sequences revealed cocirculation of closely related and divergent strains among gorillas from the same social group, indicating SIVgor transmissions within and between groups. Parental links could be inferred for some gorillas infected with closely related strains, suggesting vertical transmission, but horizontal transmission by sexual or aggressive behavior was also suspected. Intrahost molecular evolution in one gorilla over a 5-year period showed viral adaptations characteristic of escape mutants, i.e., V1V2 loop elongation and an increased number of glycosylation sites. Here we show for the first time the feasibility of noninvasive monitoring of nonhabituated gorillas to study SIVgor infection over time at both the individual and population levels. This approach can also be applied more generally to study other pathogens in wildlife. © 2012, American Society for Microbiology.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3446613/bin/supp_86_18_9760__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC3446613/bin/JVI.01186-12_zjv999096476so1.pdf
Authors & Co-Authors
Etienne, Lucie
France, Montpellier
Recherches Translationnelles Sur le Vih et Les Maladies Infectieuses
Locatelli, Sabrina
France, Montpellier
Recherches Translationnelles Sur le Vih et Les Maladies Infectieuses
Ayouba, Ahidjo
France, Montpellier
Recherches Translationnelles Sur le Vih et Les Maladies Infectieuses
Esteban, Amandine
France, Montpellier
Recherches Translationnelles Sur le Vih et Les Maladies Infectieuses
Butel, Christelle
France, Montpellier
Recherches Translationnelles Sur le Vih et Les Maladies Infectieuses
Liégeois, Florian
France, Montpellier
Recherches Translationnelles Sur le Vih et Les Maladies Infectieuses
Aghokeng, Avelin Fobang
France, Montpellier
Recherches Translationnelles Sur le Vih et Les Maladies Infectieuses
Cameroon, Yaounde
Institut de Recherche Pour le Developpement Cameroon
Delaporte, Éric
France, Montpellier
Recherches Translationnelles Sur le Vih et Les Maladies Infectieuses
Ngole, Eitel Mpoudi
Cameroon, Yaounde
Institut de Recherche Pour le Developpement Cameroon
Peeters, Martine F.
France, Montpellier
Recherches Translationnelles Sur le Vih et Les Maladies Infectieuses
Statistics
Citations: 28
Authors: 10
Affiliations: 2
Identifiers
Doi:
10.1128/JVI.01186-12
ISSN:
0022538X
e-ISSN:
10985514
Research Areas
Genetics And Genomics
Infectious Diseases
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Cohort Study
Study Locations
Cameroon