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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Persistence of HIV-1 transmitted drug resistance mutations
Journal of Infectious Diseases, Volume 208, No. 9, Year 2013
Notification
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Description
There are few data on the persistence of individual human immunodeficiency virus type 1 (HIV-1) transmitted drug resistance (TDR) mutations in the absence of selective drug pressure. We studied 313 patients in whom TDR mutations were detected at their first resistance test and who had a subsequent test performed while ART-naive. The rate at which mutations became undetectable was estimated using exponential regression accounting for interval censoring. Most thymidine analogue mutations (TAMs) and T215 revertants (but not T215F/Y) were found to be highly stable, with NNRTI and PI mutations being relatively less persistent. Our estimates are important for informing HIV transmission models. © The Author 2013. Published by Oxford University Press on behalf of the Infectious Diseases Society of America.
Authors & Co-Authors
Castro, Hannah
United Kingdom, London
Medical Research Council
Morris, Lynn G.
United Kingdom, London
University College London
Cane, Patricia A.
United Kingdom, London
Public Health England
Asboe, David
United Kingdom, London
Chelsea and Westminster Hospital
Cambiano, Valentina
United Kingdom, London
University College London
Phillips, Andrew N.
United Kingdom, London
University College London
Dunn, David T.
United Kingdom, London
Medical Research Council
Aitken, Celia
United Kingdom, Glasgow
Gartnavel General Hospital
Pozniak, Anton Louis
United Kingdom, London
Chelsea and Westminster Hospital
Webster, Daniel Peter
United Kingdom, London
Royal Free London Nhs Foundation Trust
Dolling, David I.
United Kingdom, London
Mrc Clinical Trials Unit
Fearnhill, Esther
United Kingdom, London
Mrc Clinical Trials Unit
Porter, Kholoud
United Kingdom, London
Mrc Clinical Trials Unit
Chadwick, David Robert
United Kingdom, Middlesbrough
South Tees Hospitals Nhs Foundation Trust
Churchill, Duncan R.
United Kingdom, Worthing
University Hospitals Sussex Nhs Foundation Trust
Clark, Duncan A.
United Kingdom, London
St Bartholomew's Hospital
Collins, Simon
United Kingdom, London
Hiv I-base
Delpech, Valerie C.
United Kingdom, London
Public Health England
Geretti, Anna María
United Kingdom, Liverpool
University of Liverpool
Goldberg, David J.
United Kingdom, Glasgow
Health Protection Scotland
Hale, Antony D.
United Kingdom, Leeds
Leeds Teaching Hospitals Nhs Trust
Hué, Stéphane
United Kingdom, London
University College London
Kaye, Steve
United Kingdom, London
Imperial College London
Kellam, P.
United Kingdom, Hinxton
Wellcome Sanger Institute
Lazarus, Linda
United Kingdom, London
Public Health England
Leigh Brown, Andrew J.
United Kingdom, Edinburgh
The University of Edinburgh
MacKie, Nicola E.
United Kingdom, London
Imperial College Healthcare Nhs Trust
Orkin, Chloë M.
United Kingdom, London
St Bartholomew's Hospital
Sabin, Caroline Anne
United Kingdom, London
Ucl Medical School
Smit, Erasmus J.
United Kingdom, London
Public Health England
United Kingdom, Birmingham
Heartlands Hospital
Templeton, Kate E.
United Kingdom, Edinburgh
Royal Infirmary of Edinburgh
Tilston, Peter
United Kingdom, Manchester
Manchester Royal Infirmary
Williams, Ian G.
United Kingdom, London
University College London
Zhang, Hongyi
United Kingdom, Cambridge
Addenbrooke's Hospital
Greatorex, Jane S.
United Kingdom, Cambridge
Addenbrooke's Hospital
O'Shea, Siobhan
United Kingdom, London
Guy's and st Thomas' Nhs Foundation Trust
Mullen, Jane E.
United Kingdom, London
Guy's and st Thomas' Nhs Foundation Trust
Mbisa, Tamyo
Unknown Affiliation
Cox, Alison
United Kingdom, London
Imperial College Healthcare Nhs Trust
Tandy, Richard
United Kingdom, London
King's College Hospital
Fawcett, Tracy
United Kingdom, Leeds
Leeds Teaching Hospitals Nhs Trust
Hopkins, Mark J.
Unknown Affiliation
Ashton, Lynne J.
Unknown Affiliation
Garcia-Diaz, Ana M.
United Kingdom, London
The Royal Free Hospital
Shepherd, Jill A.
United Kingdom, Edinburgh
Royal Infirmary of Edinburgh
Schmid, Matthias Ludwig
United Kingdom, Newcastle
Royal Victoria Infirmary
Payne, Brendan Alexander Ingelby
United Kingdom, Newcastle
Royal Victoria Infirmary
Hay, Phillip E.
United Kingdom, London
St George's Hospital
Paynter, Mary
United Kingdom, London
St George's Hospital
Bibby, David F.
United Kingdom, London
St Bartholomew's Hospital
Kirk, Stuart
United Kingdom, London
University College London Hospitals Nhs Foundation Trust
Gunson, Rory N.
United Kingdom, Glasgow
West of Scotland Specialist Virology Centre
Statistics
Citations: 101
Authors: 52
Affiliations: 31
Identifiers
Doi:
10.1093/infdis/jit345
ISSN:
00221899
Research Areas
Infectious Diseases