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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Association of hepatitis B surface antigen carriage with severe malaria in Gambian children
Nature Medicine, Volume 1, No. 4, Year 1995
Notification
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Description
Severe malaria is a major cause of childhood mortality in sub-Saharan Africa but the factors predisposing children to severe forms of malaria have not been fully elucidated. In a case-control study of over 1, 200 Gambian children hepatitis B virus carriage was significantly increased amongst cases of severe malaria compared to matched controls. We suggest that this association may relate to impaired clearance of liver stage parasites in the presence of the reduced level of HLA class I antigen expression on hepatocytes infected by hepatitis B virus. If this association is causal and viral carriage predisposes to severe malaria, widespread vaccination against hepatitis B virus may reduce mortality from severe malaria. © 1995 Nature Publishing Group.
Authors & Co-Authors
Thursz, Mark R.
United Kingdom, London
Imperial College London
Kwiatkowski, Dominic P.
United Kingdom, Oxford
University of Oxford
Török, M. E.
United Kingdom, London
Imperial College London
Allsopp, Catherine E.M.
United Kingdom, Oxford
University of Oxford
Greenwood, Brian M.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Whittle, Hilton C.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Thomas, Howard C.
United Kingdom, London
Imperial College London
Hill, Adrian V. S.
United Kingdom, Oxford
University of Oxford
Statistics
Citations: 64
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1038/nm0495-374
ISSN:
10788956
e-ISSN:
1546170X
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Case-Control Study