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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Analysis of the 5q31-q33 locus shows an association between IL13-1055C/T IL-13-591A/G polymorphisms and Schistosoma haematobium infections
Journal of Immunology, Volume 174, No. 10, Year 2005
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Description
Millions of humans are exposed to schistosome infections, which cause severe kidney and liver disease and 280,000 deaths annually. Th2-mediated immunity is critical to human defenses against this pathogen and susceptibility to infection is controlled by a major genetic locus that includes IL4, IL5, and IL13 genes. These observations led us to evaluate whether certain polymorphisms in IL4, IL5, or IL13 determine schistosome infection. The study was performed in two Dogon villages where Schistosoma haematobium is endemic. Schistosome infections were evaluated by counting eggs and measuring worm Ags in urine. Genetic polymorphisms were determined by restriction enzyme analysis or by primer extension and denaturing high-performance liquid chromatography analysis. Associations were tested using family-based association tests and logistical regression analysis. The alleles IL13-1055C (p = 0.05) and IL13-591A (p = 0.01) are shown, by family-based association test, to be preferentially transmitted to children with the 10% highest infections. A logistic regression analysis that included IL13-1055 G/G, G/T and T/T genotypes, age, gender, and village of residency, applied to the whole study population, showed that subjects bearing the IL13-1055T/T genotype were on average much less infected than individuals with other genotypes. Previous studies on asthma indicated that the IL13-1055T allele increased gene transcription, which is in agreement with the fact that this cytokine enhances resistance to infection by schistosome in humans. Copyright © 2005 by The American Association of Immunologists, Inc.
Authors & Co-Authors
Kouriba, Bourèma
Mali, Bamako
University of Bamako Faculty of Medicine, Pharmacy and Odonto-stomatology
France, Paris
Inserm
Chevillard, Christophe
France, Paris
Inserm
Bream, Jay H.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Argiro, Laurent
France, Paris
Inserm
Dessein, Hélia
France, Paris
Inserm
Arnaud, Violaine
France, Paris
Inserm
Sangaré, Lansana
Mali, Bamako
University of Bamako Faculty of Medicine, Pharmacy and Odonto-stomatology
Dabo, Abdoulaye
Mali, Bamako
University of Bamako Faculty of Medicine, Pharmacy and Odonto-stomatology
Béavogui, Abdoul Habib
Mali, Bamako
University of Bamako Faculty of Medicine, Pharmacy and Odonto-stomatology
Arama, Charles
Mali, Bamako
University of Bamako Faculty of Medicine, Pharmacy and Odonto-stomatology
Traoré, Hammar Alassane
Mali, Bamako
Point g Hospital
Doumbo, Ogobara K.
Mali, Bamako
University of Bamako Faculty of Medicine, Pharmacy and Odonto-stomatology
Dessein, Alain Jacques J.
France, Paris
Inserm
Statistics
Citations: 90
Authors: 13
Affiliations: 4
Identifiers
Doi:
10.4049/jimmunol.174.10.6274
ISSN:
00221767
Research Areas
Genetics And Genomics
Maternal And Child Health
Study Design
Cross Sectional Study
Study Approach
Quantitative