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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Bioactive components of the edible strain of red alga, Chondrus crispus, enhance oxidative stress tolerance in Caenorhabditis elegans
Journal of Functional Foods, Volume 5, No. 3, Year 2013
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Description
Seaweeds are rich sources of bioactive compounds with potential health benefits. Anti-stress effects of the cultivated red alga, Chondrus crispus, were investigated in the Caenorhabditis elegans model. Methanolic extracts of C. crispus (CCME) enhanced C. elegans tolerance to juglone-induced oxidative stress and increased life span; however water extracts did not show such effects. CCME treatment reduced reactive oxygen species (ROS) in the worms and increased the transcription of stress response genes; sod3, hsp16.2, daf16 and skn1. The chemical profile of CCME revealed the presence of unsaturated fatty acids, pigments, galactolipids, floridoside, isothionic acid, taurine, phenylalanine and l-citruline. Bioassay guided fractionation revealed that fatty acids, lipids and pigments imparted stress tolerance. Taken together, our results suggest that organic fractions of cultivated C. crispus impart oxidative stress tolerance in C. elegans, possibly by altering the stress response pathways. © 2013 Elsevier Ltd.
Authors & Co-Authors
Sangha, Jatinder Singh
Canada, Halifax
Dalhousie University
Fan, Di
Canada, Halifax
Dalhousie University
Banskota, Arjun H.
Canada, Ottawa
National Research Council Canada
Stefanova, Roumiana
Canada, Ottawa
National Research Council Canada
Khan, Wajahatullah M.
Saudi Arabia, Riyadh
College of Sciences
Hafting, Jeff
Canada, Dartmouth
Acadian Seaplants Limited
Craigie, James
Canada, Ottawa
National Research Council Canada
Critchley, Alan T.
Canada, Dartmouth
Acadian Seaplants Limited
Prithiviraj, Balakrishnan
Canada, Halifax
Dalhousie University
Statistics
Citations: 38
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1016/j.jff.2013.04.001
ISSN:
17564646
Research Areas
Environmental