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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Analysis of Candida auris fungemia at a single facility in Kenya
International Journal of Infectious Diseases, Volume 85, Year 2019
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Description
Objectives: Candida auris emerged as a human pathogen in 2009 and has subsequently been identified around the world as a cause of invasive candidiasis. We did an analysis from a single institution in order to analyze risk factors and outcomes for C. auris candidemia. Methods: Patients with candidemia were identified by the electronic medical record and reviewed for risk factors and outcome. Candida isolates were identified by Vitek2 as Candida haemulonii, but species determinations for 21 of the isolates using published molecular and proteomic methods identified all as C. auris. Findings: From September 2010 to December 2016, C. auris accounted for 38% of 201 patients with candidemia, while C. albicans contributed 25%. C. auris patients had been hospitalized longer (mean 32 days vs. 13 days; p < 0.001), were more likely to have central lines preceding candidemia than C. albicans patients (84% vs. 54%; p = < 0.001) and had more commonly been treated with carbapenems (83% vs 61% for C. albicans [p = 0.01]). The crude mortality was 29%, compared to 36% for C. albicans. Conclusions: These findings suggest an opportunistic pathogen that may be less virulent, but difficult to eradicate and that control efforts should focus on antimicrobial usage. © 2019 The Authors
Authors & Co-Authors
Adam, Rodney D.
Pakistan, Karachi
The Aga Khan University
Revathi, Gunturu N.
Pakistan, Karachi
The Aga Khan University
Okinda, Nancy A.
Pakistan, Karachi
The Aga Khan University
Shah, Jasmit S.
Pakistan, Karachi
The Aga Khan University
Kagotho, Elizabeth
Pakistan, Karachi
The Aga Khan University
Castanheira, Mariana
United States, North Liberty
Jmi Laboratories Incorporated
Pfaller, Michael A.
United States, North Liberty
Jmi Laboratories Incorporated
Maina, Daniel N.
Pakistan, Karachi
The Aga Khan University
Statistics
Citations: 34
Authors: 8
Affiliations: 2
Identifiers
Doi:
10.1016/j.ijid.2019.06.001
ISSN:
12019712
Research Areas
Health System And Policy
Study Locations
Kenya