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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Human dectin-1 deficiency and mucocutaneous fungal infections
New England Journal of Medicine, Volume 361, No. 18, Year 2009
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Description
Mucocutaneous fungal infections are typically found in patients who have no known immune defects. We describe a family in which four women who were affected by either recurrent vulvovaginal candidiasis or onychomycosis had the early-stop-codon mutation Tyr238X in the β-glucan receptor dectin-1. The mutated form of dectin-1 was poorly expressed, did not mediate β-glucan binding, and led to defective production of cytokines (interleukin-17, tumor necrosis factor, and interleukin-6) after stimulation with β-glucan or Candida albicans. In contrast, fungal phagocytosis and fungal killing were normal in the patients, explaining why dectin-1 deficiency was not associated with invasive fungal infections and highlighting the specific role of dectin-1 in human mucosal antifungal defense. Copyright © 2009 Massachusetts Medical Society.
Authors & Co-Authors
Ferwerda, Bart
Netherlands, Nijmegen
Radboud University Medical Center
Ferwerda, Gerben
Netherlands, Nijmegen
Radboud University Medical Center
Plantinga, Theo S.
Netherlands, Nijmegen
Radboud University Medical Center
Willment, Janet Anne
South Africa, Cape Town
University of Cape Town
Van Spriel, Annemiek B.
Netherlands, Nijmegen
Radboud Institute for Molecular Life Sciences
Venselaar, Hanka
Netherlands, Nijmegen
Radboud Institute for Molecular Life Sciences
Elbers, Clara C.
Netherlands, Utrecht
University Medical Center Utrecht
Johnson, Melissa D.
United States, Durham
Duke University Medical Center
Cambi, Alessandra
Netherlands, Nijmegen
Radboud Institute for Molecular Life Sciences
Huysamen, Cristal
South Africa, Cape Town
University of Cape Town
Jacobs, Liesbeth
Netherlands, Nijmegen
Radboud University Medical Center
Jansen, Trees
Netherlands, Nijmegen
Radboud University Medical Center
Verheijen, Karlijn
Netherlands, Nijmegen
Radboud University Medical Center
Masthoff, Laury
Netherlands, Nijmegen
Radboud University Medical Center
Morré, Servaas Å.
Netherlands, Amsterdam
Vrije Universiteit Amsterdam
Vriend, Gert
Netherlands, Nijmegen
Radboud Institute for Molecular Life Sciences
Williams, David L.
United States, Johnson
East Tennessee State University
Perfect, John R.
United States, Durham
Duke University Medical Center
Joosten, Leo A.B.
Netherlands, Nijmegen
Radboud University Medical Center
Wijmenga, Cisca
Netherlands, Utrecht
University Medical Center Utrecht
Netherlands, Groningen
Universitair Medisch Centrum Groningen
van der Meer, Jos W.M.D.
Netherlands, Nijmegen
Radboud University Medical Center
Adema, Gosse J.
Netherlands, Nijmegen
Radboud Institute for Molecular Life Sciences
Kullberg, Bart Jan
Netherlands, Nijmegen
Radboud University Medical Center
Brown, Gordon D.A.
South Africa, Cape Town
University of Cape Town
Netea, Mihai Gheorghe
Netherlands, Nijmegen
Radboud University Medical Center
Statistics
Citations: 25
Authors: 25
Affiliations: 8
Identifiers
Doi:
10.1056/NEJMoa0901053
ISSN:
00284793
e-ISSN:
15334406
Research Areas
Cancer
Genetics And Genomics
Participants Gender
Female