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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
neuroscience
Associations of maternal long-chain polyunsaturated fatty acids, methyl mercury, and infant development in the Seychelles Child Development Nutrition Study
NeuroToxicology, Volume 29, No. 5, Year 2008
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Description
Fish consumption during gestation can provide the fetus with long-chain polyunsaturated fatty acids (LCPUFA) and other nutrients essential for growth and development of the brain. However, fish consumption also exposes the fetus to the neurotoxicant, methyl mercury (MeHg). We studied the association between these fetal exposures and early child development in the Seychelles Child Development Nutrition Study (SCDNS). Specifically, we examined a priori models of Ω-3 and Ω-6 LCPUFA measures in maternal serum to test the hypothesis that these LCPUFA families before or after adjusting for prenatal MeHg exposure would reveal associations with child development assessed by the BSID-II at ages 9 and 30 months. There were 229 children with complete outcome and covariate data available for analysis. At 9 months, the PDI was positively associated with total Ω-3 LCPUFA and negatively associated with the ratio of Ω-6/Ω-3 LCPUFA. These associations were stronger in models adjusted for prenatal MeHg exposure. Secondary models suggested that the MeHg effect at 9 months varied by the ratio of Ω-6/Ω-3 LCPUFA. There were no significant associations between LCPUFA measures and the PDI at 30 months. There were significant adverse associations, however, between prenatal MeHg and the 30-month PDI when the LCPUFA measures were included in the regression analysis. The BSID-II mental developmental index (MDI) was not associated with any exposure variable. These data support the potential importance to child development of prenatal availability of Ω-3 LCPUFA present in fish and of LCPUFA in the overall diet. Furthermore, they indicate that the beneficial effects of LCPUFA can obscure the determination of adverse effects of prenatal MeHg exposure in longitudinal observational studies. © 2008 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Strain, J. J.
United Kingdom, Coleraine
Ulster University
Davidson, Philip W.
United States, Rochester
University of Rochester School of Medicine and Dentistry
Bonham, Maxine P.
United Kingdom, Coleraine
Ulster University
McSorley, Emeir M.
United Kingdom, Coleraine
Ulster University
Stokes-Riner, Abbie
United States, Rochester
University of Rochester School of Medicine and Dentistry
Thurston, Sally W.
United States, Rochester
University of Rochester School of Medicine and Dentistry
Wallace, Julie M.W.
United Kingdom, Coleraine
Ulster University
Robson, Paula J.
United Kingdom, Coleraine
Ulster University
Shamlaye, Conrad F.
Seychelles, Mahe
Ministry of Health Seychelles
Georger, Lesley A.
United States, Rochester
University of Rochester School of Medicine and Dentistry
Sloane-Reeves, Jean E.
United States, Rochester
University of Rochester School of Medicine and Dentistry
Cernichiari, Elsa
United States, Rochester
University of Rochester School of Medicine and Dentistry
Canfield, Richard L.
United States, Ithaca
Cornell University
Cox, Christopher F.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Huang, L. S.
United States, Rochester
University of Rochester School of Medicine and Dentistry
Janciuras, Joanne
United States, Rochester
University of Rochester School of Medicine and Dentistry
Myers, Gary J.
United States, Rochester
University of Rochester School of Medicine and Dentistry
Clarkson, Thomas William
United States, Rochester
University of Rochester School of Medicine and Dentistry
Statistics
Citations: 223
Authors: 18
Affiliations: 5
Identifiers
Doi:
10.1016/j.neuro.2008.06.002
ISSN:
0161813X
Research Areas
Food Security
Maternal And Child Health
Study Design
Cohort Study
Study Approach
Quantitative
Study Locations
Seychelles