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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Caveolin-1 promotes pancreatic cancer cell differentiation and restores membranous E-cadherin via suppression of the epithelial-mesenchymal transition
Cell Cycle, Volume 10, No. 21, Year 2011
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Description
Pancreatic cancer is one of the deadliest cancers due to early rapid metastasis and chemoresistance. Recently, epithelial to mesenchymal transition (EMT) was shown to play a key role in the pathogenesis of pancreatic cancer. To understand the role of caveolin-1 (Cav-1) in EMT, we overexpressed Cav-1 in a pancreatic cancer cell line, Panc 10.05, that does not normally express Cav-1. Here, we show that Cav-1 expression in pancreatic cancer cells induces an epithelial phenotype and promotes cell-cell contact, with increased expression of plasma membrane bound E-cadherin and β-catenin. Mechanistically, Cav-1 induces Snail downregulation and decreased activation of AKT, MAPK and TGFβ-Smad signaling pathways. In vitro, Cav-1 expression reduces cell migration and invasion, and attenuates doxorubicin-chemoresistance of pancreatic cancer cells. Importantly, in vivo studies revealed that Cav-1 expression greatly suppresses tumor formation in a xenograft model. Most interestingly, Panc/Cav-1 tumors displayed organized nests of differentiated cells that were totally absent in control tumors. Confirming our in vitro results, these nests of differentiated cells showed reexpression of E-cadherin and β-catenin at the cell membrane. Thus, we provide evidence that Cav-1 functions as a crucial modulator of EMT and cell differentiation in pancreatic cancer. © 2011 Landes Bioscience.
Authors & Co-Authors
Salem, Ahmed F.
United States, Philadelphia
Sidney Kimmel Cancer Center at Jefferson
Italy, Pisa
Università Di Pisa
Bonuccelli, Gloria
United States, Philadelphia
Sidney Kimmel Cancer Center at Jefferson
Bevilacqua, Generoso
United States, Philadelphia
Thomas Jefferson University
Arafat, Hwyda
Egypt, Cairo
National Organization for Drug Control and Research Egypt
Pestell, R.
United States, Philadelphia
Sidney Kimmel Cancer Center at Jefferson
Sotgia, Federica
United States, Philadelphia
Sidney Kimmel Cancer Center at Jefferson
Lisanti, Michael P.
United States, Philadelphia
Sidney Kimmel Cancer Center at Jefferson
Statistics
Citations: 48
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.4161/cc.10.21.17895
ISSN:
15384101
e-ISSN:
15514005
Research Areas
Cancer