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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Association between osteocalcin, metabolic syndrome, and cardiovascular risk factors: Role of total and undercarboxylated osteocalcin in patients with type 2 diabetes
International Journal of Endocrinology, Volume 2013, Article 197519, Year 2013
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Description
Studies have demonstrated that total osteocalcin (TOC) is associated with metabolic syndrome (MetS) and therefore might influence the risk of cardiovascular disease in humans. Undercarboxylated osteocalcin (uOC) regulates insulin secretion and sensitivity in mice, but its relation to MetS in humans is unclear. We aimed to determine whether uOC is related to MetS and/or its individual components and other cardiovascular risk factors in patients with type 2 diabetes mellitus (T2DM), and whether TOC and uOC have utility in predicting the cardiovascular risk. We studied 203 T2DM patients with and without MetS. MetS was defined based on the NCEP-ATP III criteria. A correlation analysis was performed between the three outcome variables: (i) TOC, (ii) uOC, and (iii) carboxylated osteocalcin (cOC) and MetS components and other cardiovascular risk factors. Both TOC and uOC were significantly lower in patients with MetS compared to those without MetS, independent of body mass index. In patients with MetS, uOC was significantly and positively correlated with HDL cholesterol, while TOC was significantly and negatively correlated with serum triglycerides. We report for the first time that uOC is related to lipid indices in patients with T2DM. Further studies are necessary to determine whether uOC can be utilized for cardiovascular risk assessments in these patients. © 2013 Assim A. Alfadda et al.
Authors & Co-Authors
Alfadda, Assim A.
Saudi Arabia, Riyadh
College of Medicine
Masood, Afshan
Saudi Arabia, Riyadh
College of Medicine
Shaikh, Shaffi Ahamed
Saudi Arabia, Riyadh
College of Medicine
Dekhil, Hafedh
Saudi Arabia, Riyadh
College of Medicine
Goran, Michael
United States, Los Angeles
University of Southern California
Statistics
Citations: 49
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1155/2013/197519
ISSN:
16878337
e-ISSN:
16878345
Research Areas
Noncommunicable Diseases
Study Approach
Quantitative