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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
The diagnostic value and safety of transbronchial needle aspiration biopsy in children with mediastinal lymphadenopathy
Pediatric Pulmonology, Volume 45, No. 12, Year 2010
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Description
Introduction Anterior mediastinal masses in children can have different causes which includes, Mycobacterium tuberculosis (MTB) or malignant lymphadenopathy. Transbronchial needle aspiration (TBNA) has been described as a safe and effective diagnostic procedure in adult patients with lung cancer. Aim To describe the use of TBNA as a diagnostic test in children with large subcarinal lymphadenopathy and to determine the safety of the procedure in children. Patients and Methods Prospective descriptive study of children with subcarinal mediastinal lymph nodes who underwent TBNA. The majority of the children were referred due to treatment failure. Children were enrolled if the diagnosis remained unclear after computer tomography of the chest. Results Thirty patients were enrolled in this study; TBNA was done in 28 patients. A definitive diagnosis was made by TBNA in 54% (na=15) of patients; MTB lymphadenopathy (na=13), metastatic nephroblastoma (na=1), and fibrosing mediastinitis (na=1). In seven (25%) cases the TBNA was the sole source of the specimens from which the definitive diagnosis was made. No serious complications were encountered during or after the procedure. Conclusion TBNA is a safe procedure in children with mediastinal lymphadenopathy of unknown cause resulting in a definitive diagnosis in 57% of cases. TBNA adds additional value to flexible bronchoscopy in the diagnosis of mediastinal lymphadenopathy in children. © 2010 Wiley-Liss, Inc.
Authors & Co-Authors
Goussard, Pierre
South Africa, Stellenbosch
Stellenbosch University
Gie, Robert Peter
South Africa, Stellenbosch
Stellenbosch University
Kling, Sharon
South Africa, Stellenbosch
Stellenbosch University
de la Rey Nel, Etienne
South Africa, Stellenbosch
Stellenbosch University
Louw, Mercia
South Africa, Stellenbosch
Stellenbosch University
Schubert, Pawel Tomasz
South Africa, Stellenbosch
Stellenbosch University
Rhode, Delano
South Africa, Stellenbosch
Stellenbosch University
Vanker, Aneesa
South Africa, Stellenbosch
Stellenbosch University
Andronikou, Savvas K.D.
South Africa, Cape Town
University of Cape Town
Statistics
Citations: 43
Authors: 9
Affiliations: 2
Identifiers
Doi:
10.1002/ppul.21303
ISSN:
10990496
Research Areas
Cancer
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study