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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Interleukin 12B (IL12B) genetic variation and pulmonary tuberculosis: A study of cohorts from the Gambia, Guinea-Bissau, United States and Argentina
PLoS ONE, Volume 6, No. 2, Article e16656, Year 2011
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Description
We examined whether polymorphisms in interleukin-12B (IL12B) associate with susceptibility to pulmonary tuberculosis (PTB) in two West African populations (from The Gambia and Guinea-Bissau) and in two independent populations from North and South America. Nine polymorphisms (seven SNPs, one insertion/deletion, one microsatellite) were analyzed in 321 PTB cases and 346 controls from Guinea-Bissau and 280 PTB cases and 286 controls from The Gambia. For replication we studied 281 case and 179 control African-American samples and 221 cases and 144 controls of European ancestry from the US and Argentina. First-stage single locus analyses revealed signals of association at IL12B 3′ UTR SNP rs3212227 (unadjusted allelic p = 0.04; additive genotypic p = 0.05, OR = 0.78, 95% CI [0.61-0.99]) in Guinea-Bissau and rs11574790 (unadjusted allelic p = 0.05; additive genotypic p = 0.05, OR = 0.76, 95% CI [0.58-1.00]) in The Gambia. Association of rs3212227 was then replicated in African-Americans (rs3212227 allelic p = 0.002; additive genotypic p = 0.05, OR = 0.78, 95% CI [0.61-1.00]); most importantly, in the African-American cohort, multiple significant signals of association (seven of the nine polymorphisms tested) were detected throughout the gene. These data suggest that genetic variation in IL12B, a highly relevant candidate gene, is a risk factor for PTB in populations of African ancestry, although further studies will be required to confirm this association and identify the precise mechanism underlying it. © 2011 Morris et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3037276/bin/pone.0016656.s001.ppt
https://efashare.b-cdn.net/share/pmc/articles/PMC3037276/bin/pone.0016656.s002.ppt
https://efashare.b-cdn.net/share/pmc/articles/PMC3037276/bin/pone.0016656.s003.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC3037276/bin/pone.0016656.s004.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC3037276/bin/pone.0016656.s005.doc
Authors & Co-Authors
Morris, Gerard A.J.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Edwards, Digna R.Velez
Italy, Rome
Ospedale San Pietro Fatebenefratelli
United States, Miami
University of Miami Leonard M. Miller School of Medicine
United States, Nashville
Vanderbilt University Medical Center
Hill, Philip C.
Gambia, Banjul
Medical Research Council Laboratories Gambia
New Zealand, Dunedin
University of Otago
Wejse, Christian
Denmark, Aarhus
Aarhus Universitetshospital
Guinea-bissau, Bissau
Bandim Health Project
Bisseyé, Cyrille
Gambia, Banjul
Medical Research Council Laboratories Gambia
Olesen, Rikke Mørch
Denmark, Aarhus
Aarhus Universitetshospital
Edwards, Todd L.
Italy, Rome
Ospedale San Pietro Fatebenefratelli
United States, Miami
University of Miami Leonard M. Miller School of Medicine
United States, Nashville
Vanderbilt University Medical Center
Gilbert, John R.
United States, Miami
University of Miami Leonard M. Miller School of Medicine
Myers, Jamie L.
United States, Miami
University of Miami Leonard M. Miller School of Medicine
Stryjewski, Martín E.
Argentina, Buenos Aires
Centro de Educacion Medica e Investigaciones Clinicas Norberto Quirno
Abbate, Eduardo H.
Argentina, Buenos Aires
Hospital de Infecciosas Francisco Javier Muniz
Estevan, Rosa
Argentina, Buenos Aires
Hospital de Infecciosas Francisco Javier Muniz
Hamilton, Carol Dukes
United States, Durham
Fhi 360
United States, Durham
Duke University Medical Center
Tacconelli, Alessandra
Italy, Rome
Ospedale San Pietro Fatebenefratelli
Novelli, Giuseppe
Italy, Rome
Università Degli Studi Di Roma Tor Vergata
Brunetti, Ercole
Italy, Rome
Ospedale San Pietro Fatebenefratelli
Aaby, Peter
Guinea-bissau, Bissau
Bandim Health Project
Sodemann, Morten
Denmark, Odense
Syddansk Universitet
Østergaard, Lars Jørgen
Denmark, Aarhus
Aarhus Universitetshospital
Adegbola, Richard A.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Williams, Scott M.
United States, Nashville
Vanderbilt University Medical Center
Scott, William K.
United States, Miami
University of Miami Leonard M. Miller School of Medicine
Sirugo, G.
Italy, Rome
Ospedale San Pietro Fatebenefratelli
Statistics
Citations: 44
Authors: 23
Affiliations: 13
Identifiers
Doi:
10.1371/journal.pone.0016656
e-ISSN:
19326203
Research Areas
Genetics And Genomics
Study Design
Cohort Study
Study Locations
Gambia
Guinea
Guinea-Bissau