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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Impact of vitamin A with zinc supplementation on malaria morbidity in Ghana
Nutrition Journal, Volume 12, No. 1, Article 131, Year 2013
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Description
Background: Malaria is a leading cause of morbidity and mortality among young children and is estimated to cause at least 1 million deaths each year especially among pregnant women and young children under the age of five years. Vitamin A supplementation is known to reduce morbidity and mortality in young children. Zinc is required for growth and immunity and we sought to replicate the study by Zeba et al. which showed 30% lower cases of clinical malaria in children on a combination of zinc and a large dose of vitamin A compared with children on vitamin A alone based on the hypothesis that combined vitamin A and zinc reduced symptomatic malaria compared to vitamin A alone. Objectives. The primary objective was to determine the effect of vitamin A alone vs. vitamin A and zinc supplements on the incidence of clinical malaria and other anthropometric indices. It also sought to assess the effects on the incidence of anaemia, diarrhoea and pneumonia. Methods. The study was community-based and 200 children between the ages of 6-24 months were randomised to receive either vitamin A (100,000 IU for infants less than 12 months & 200,000 IU for children greater than 12 months and 10 mg daily zinc in the intervention group or vitamin A and zinc placebo for 6 months in the control group. Results: The number of children who were diagnosed with uncomplicated malaria in the intervention group was 27% significantly lower compared with the children in the control group (p = 0.03). There were, however, no effects on severe malaria, pneumonia, anaemia and diarrhea. Conclusions: Our study confirms a significant role of vitamin A and zinc in reducing malaria morbidity. © 2013 Owusu-Agyei et al.; licensee BioMed Central Ltd.
Authors & Co-Authors
Owusu-Agyei, Seth
Ghana, Kintampo
Kintampo Health Research Centre
Newton, Sam Kofi Tekyi
Ghana, Kintampo
Kintampo Health Research Centre
Mahama, Emmanuel N.
Ghana, Kintampo
Kintampo Health Research Centre
Febir, Lawrence Gyabaa
Ghana, Kintampo
Kintampo Health Research Centre
Abdulai, Martha Ali
Ghana, Kintampo
Kintampo Health Research Centre
Adjei, Kwame
Ghana, Kintampo
Kintampo Health Research Centre
Tchum, Kofi
Ghana, Kintampo
Kintampo Health Research Centre
Alhassan, Latifa
Ghana, Kintampo
Kintampo Health Research Centre
Moleah, Thabisile
Austria, Vienna
International Atomic Energy Agency, Vienna
Tanumihardjo, Sherry Ann
United States, Madison
University of Wisconsin-madison
Statistics
Citations: 37
Authors: 10
Affiliations: 3
Identifiers
Doi:
10.1186/1475-2891-12-131
e-ISSN:
14752891
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Randomised Control Trial
Cohort Study
Study Locations
Ghana
Participants Gender
Female