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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Acute generalized exanthematous pustulosis (AGEP) induced by cefotaxime
Fundamental and Clinical Pharmacology, Volume 24, No. 4, Year 2010
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Description
We report a case of acute generalized exanthematous pustulosis (AGEP) after cefotaxime use confirmed by a positive patch test. A 30-year-old woman received cefotaxime, fosfomycin and ciprofloxacin for sinusitis. Twelve days after drug initiation, she developed an extending pustular erythema associated with fever. Laboratory investigations showed marked leukocytosis. His blood chemistry was normal. The histological examination showed parakeratosis, spongiosis and nonfollicular intra-epidermal pustules consistent with AGEP. All medications were withdrawn. The symptoms resolved within 11 days after cefotaxime discontinuation. Patch tests were positive to cefotaxime after 48 h, while ciprofloxacin and fosfomycin yielded negative findings. Based on the Naranjo algorithm, it is probable that AGEP reaction was caused by cefotaxime. To our knowledge, this is the first reported case of AGEP associated with positive cefotaxime patch testing. © 2009 Société Française de Pharmacologie et de Thérapeutique.
Authors & Co-Authors
Chaabane, Amel
Tunisia, Monastir
Université de Monastir
Aouam, Karim
Tunisia, Monastir
Université de Monastir
Gassab, Lies
Tunisia, Monastir
Monastir Hospital
Njim, Leïla
Tunisia, Monastir
Monastir Hospital
Boughattas, Naceur Abderrazak
Tunisia, Monastir
Université de Monastir
Statistics
Citations: 30
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1111/j.1472-8206.2009.00794.x
ISSN:
07673981
e-ISSN:
14728206
Participants Gender
Female