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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Nanocarriers for cytoplasmic delivery: Cellular uptake and intracellular fate of chitosan and hyaluronic acid-coated chitosan nanoparticles in a phagocytic cell model
Macromolecular Bioscience, Volume 11, No. 12, Year 2011
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Description
The cellular uptake of hyaluronic-acid-coated, negatively charged chitosan/triphosphate nanoparticles and that of uncoated, positively charged ones is investigated by studying cellular localization, uptake kinetics and mechanism of internalization in J774.2 macrophages, using non-phagocytic L929 fibroblasts as a control for uncoated nanoparticles. Both kinds of nanoparticles undergo endosomal escape and adopt a similar clathrin-based endocytic mechanism. The surface decoration with HA profoundly influences the kinetics of cellular uptake, with an at least two orders of magnitude slower kinetics, but also the nature of the binding on the cellular surface. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Authors & Co-Authors
Rayad, Noha Z.
Egypt, Cairo
Faculty of Pharmacy - Ain Shams University
Nasti, Alessandro
United Kingdom, Manchester
The University of Manchester
Italy, Naples
Università Degli Studi Di Napoli Federico Ii
United Kingdom, Lincoln
Lincoln County Hospital
Tirelli, Nicola
United Kingdom, Manchester
The University of Manchester
Statistics
Citations: 106
Authors: 3
Affiliations: 4
Identifiers
Doi:
10.1002/mabi.201100156
ISSN:
16165187
e-ISSN:
16165195