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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Mammographic density and candidate gene variants: A twins and sisters study
Cancer Epidemiology Biomarkers and Prevention, Volume 16, No. 7, Year 2007
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Description
Background: Mammographic density, the light/white radiographic appearance on a mammogram that represents connective and epithelial tissue, is a strong risk factor for breast cancer which seems to be highly heritable. Little is known about its genetic determinants. Methods: We studied 457 women from 207 sisterhoods (104 monozygotic twins, 182 dizygotic twins, and 171 singletons). Percentage mammographic density (PMD) as well as dense area and nondense area were calculated using a computer-assisted method. We measured six single nucleotide polymorphisms from six candidate genes (COMT, HSD3B1, IGFBP3, HER2, XPD, and XRCC3). Associations between genotypes and mammographic measures were tested (a) cross-sectionally using a multivariate normal model fitted using FISHER that allowed separate correlations for monozygotic, dizygotic, and nontwin pairs and (b) within sister pairs using paired t tests. Results: Cross-sectionally, each additional copy of the HSD3B1 Asn367Thr variant allele was associated with lower PMD (-3.47% per allele; SE = 1.65; P = 0.035). Within-pair regression estimates confirmed this association. There was no evidence for an association between the mammographic density measures and any of the other variants studied. Conclusion: We have replicated an association between a variant in the HSD3B1 gene and PMD, which suggests that HSD3B1 may be genetic determinant of mammographic density. Copyright © 2007 American Association for Cancer Research.
Authors & Co-Authors
Stone, Jennifer L.
Australia, Melbourne
University of Melbourne
Byrnes, Graham B.
Australia, Melbourne
University of Melbourne
Dite, Gillian S.
Australia, Melbourne
University of Melbourne
Southey, Melissa Caroline
Australia, Melbourne
University of Melbourne
Hayes, Vanessa M.
Australia, Sydney
Garvan Institute of Medical Research
Australia, Sydney
St. Vincent's Hospital Sydney
Hopper, John Llewelyn
Australia, Melbourne
University of Melbourne
Statistics
Citations: 33
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.1158/1055-9965.EPI-07-0107
ISSN:
10559965
Research Areas
Cancer
Genetics And Genomics
Participants Gender
Female