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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Antibodies against malaria and Epstein-Barr virus in childhood Burkitt lymphoma: A case-control study in Uganda
International Journal of Cancer, Volume 122, No. 6, Year 2008
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Description
Burkitt lymphoma, a childhood tumor common in parts of sub-Saharan Africa, has been directly associated with Epstein-Barr virus (EBV) and indirectly with prevalence of malaria. We studied antibodies to both EBV and malaria in children diagnosed with this cancer in Uganda. We performed a case-control study of HIV-seronegative children (≤15 years) admitted to hospital. Cases were diagnosed with Burkitt lymphoma and controls with non-malignant conditions or non-lymphatic cancers. Interviews were conducted and serological samples collected and, when possible, tested for both EBV and malaria. Adjusted odds ratios (ORs) for Burkitt lymphoma were estimated using unconditional logistic regression adjusting for sex, age, residential district, household income and tribe. The mean age of cases was 7 years and 61% were male. Compared to controls, cases were more likely to be reported having received more frequent treatment for malaria in the past year (OR = 2.0; p = 0.001) and less likely to be living in a home where insecticides were used (OR = 0.2; p < 0.0001). Odds ratios for Burkitt lymphoma in children increased with increasing antibody levels against EBV (p < 0.0001) and malaria (p = 0.05). Findings were similar for children residing in districts close to the capital city and in remote areas. Cases were 5 times more likely than controls to have raised levels of both EBV and malaria antibodies (OR = 5.0; p = 0.003). Our findings suggest that EBV and malaria may act synergistically in the pathogenesis of childhood Burkitt lymphoma. Malaria prevention measures may also prevent this childhood cancer. © 2007 Wiley-Liss, Inc.
Authors & Co-Authors
Carpenter, Lucy J.
United Kingdom, Oxford
University of Oxford
Newton, Robert A.
United Kingdom, York
University of York
Casabonne, Delphine
United Kingdom, Oxford
University of Oxford Medical Sciences Division
Ziegler, John L.
Uganda, Kampala
School of Medicine, Makerere University College of Health Sciences
Mbulaiteye, Sam M.
United States, Rockville
National Cancer Institute Nci
Mbidde, Edward Katongole
Uganda, Kampala
School of Medicine, Makerere University College of Health Sciences
Wabinga, Henry R.
Uganda, Kampala
School of Medicine, Makerere University College of Health Sciences
Jaffe, Harold W.
United Kingdom, Oxford
University of Oxford
Beral, Valerie
United Kingdom, Oxford
University of Oxford Medical Sciences Division
Statistics
Citations: 101
Authors: 9
Affiliations: 5
Identifiers
Doi:
10.1002/ijc.23254
ISSN:
00207136
e-ISSN:
10970215
Research Areas
Cancer
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Case-Control Study
Study Locations
Uganda
Participants Gender
Male