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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Epidemiology and outcomes of hospital-acquired bloodstream infections in intensive care unit patients: the EUROBACT-2 international cohort study
Intensive Care Medicine, Volume 49, No. 2, Year 2023
Notification
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Description
Purpose: In the critically ill, hospital-acquired bloodstream infections (HA-BSI) are associated with significant mortality. Granular data are required for optimizing management, and developing guidelines and clinical trials. Methods: We carried out a prospective international cohort study of adult patients (≥ 18 years of age) with HA-BSI treated in intensive care units (ICUs) between June 2019 and February 2021. Results: 2600 patients from 333 ICUs in 52 countries were included. 78% HA-BSI were ICU-acquired. Median Sequential Organ Failure Assessment (SOFA) score was 8 [IQR 5; 11] at HA-BSI diagnosis. Most frequent sources of infection included pneumonia (26.7%) and intravascular catheters (26.4%). Most frequent pathogens were Gram-negative bacteria (59.0%), predominantly Klebsiella spp. (27.9%), Acinetobacter spp. (20.3%), Escherichia coli (15.8%), and Pseudomonas spp. (14.3%). Carbapenem resistance was present in 37.8%, 84.6%, 7.4%, and 33.2%, respectively. Difficult-to-treat resistance (DTR) was present in 23.5% and pan-drug resistance in 1.5%. Antimicrobial therapy was deemed adequate within 24 h for 51.5%. Antimicrobial resistance was associated with longer delays to adequate antimicrobial therapy. Source control was needed in 52.5% but not achieved in 18.2%. Mortality was 37.1%, and only 16.1% had been discharged alive from hospital by day-28. Conclusions: HA-BSI was frequently caused by Gram-negative, carbapenem-resistant and DTR pathogens. Antimicrobial resistance led to delays in adequate antimicrobial therapy. Mortality was high, and at day-28 only a minority of the patients were discharged alive from the hospital. Prevention of antimicrobial resistance and focusing on adequate antimicrobial therapy and source control are important to optimize patient management and outcomes. © 2023, Springer-Verlag GmbH Germany, part of Springer Nature.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC9916499/bin/134_2022_6944_MOESM1_ESM.pdf
Authors & Co-Authors
Tabah, Alexis
Australia, Redcliffe
Redcliffe Hospital
Australia, Brisbane
Queensland Critical Care Research Network Qccrn
Australia, Brisbane
Queensland University of Technology
Australia, Brisbane
The University of Queensland
Buetti, N.
Switzerland, Geneva
Organisation Mondiale de la Santé
France, Paris
Inserm
Staiquly, Quentin
France, Fontaine
Biometry
Ruckly, Stéphane
France, Paris
Inserm
France, Fontaine
Biometry
Akova, Murat
Turkey, Ankara
Hacettepe Üniversitesi
Aslan, Abdullah Tarık
Turkey, Ankara
Hacettepe Üniversitesi
Léone, Marc
France, Marseille
Hôpital Nord Ap-hm
Conway-Morris, Andrew
United Kingdom, Cambridge
University of Cambridge
United Kingdom, Cambridge
Addenbrooke's Hospital
Bassetti, Matteo
Italy, Genoa
Università Degli Studi Di Genova
Arvaniti, Kostoula
Greece, Thessaloniki
Papageorgiou University Affiliated Hospital
Lipman, Jeffrey
Australia, Brisbane
The University of Queensland
France, Montpellier
Université de Montpellier
Australia, Brisbane
Royal Brisbane and Women's Hospital
Ferrer-Roca, Ricard
Spain, Barcelona
Hospital Universitari Vall D'hebron
Qiu, Haibo
Unknown Affiliation
Paiva, José Artur
Portugal, Porto
Centro Hospitalar Universitário de São João
Portugal, Porto
Universidade do Porto
Portugal, Porto
Infection and Sepsis Id Group
Póvoa, Pedro R.
Portugal, Lisbon
Universidade Nova de Lisboa
Denmark, Odense
Odense Universitetshospital
Portugal, Lisbon
Hospital São Francisco Xavier
de Bus, Liesbet
Belgium, Ghent
Universitair Ziekenhuis Gent
De Waele, Jan J.
Belgium, Ghent
Universiteit Gent
Belgium, Ghent
Universitair Ziekenhuis Gent
Zand, Farid
Iran, Shiraz
Shiraz University of Medical Sciences
Gurjar, Mohan
India, Lucknow
Sanjay Gandhi Postgraduate Institute of Medical Sciences
Alsisi, Adel Mohamed Yasin
United Arab Emirates, Dubai
Prime Hospital
Egypt, Giza
Cairo University
Abidi, Khalid
Morocco, Rabat
Faculté de Médecine et de Pharmacie de Rabat
Bracht, Hendrik
Germany, Ulm
Universitätsklinikum Ulm
Hayashi, Yoshiro
Japan, Kamogawa
Kameda General Hospital
Jeon, Kyeongman
South Korea, Suwon
Skku School of Medicine
Elhadi, Muhammed K.
Libya, Tripoli
University of Tripoli
Barbier, François S.
France, Orleans
Chr D'orléans
Timsit, Jean Franc¸ois
France, Paris
Inserm
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Pollock, Hamish H.G.
Unknown Affiliation
Margetts, Ben K.
Unknown Affiliation
Young, Meredith E.
Unknown Affiliation
Bhadange, Neeraj
Unknown Affiliation
Tyler, Steven
Unknown Affiliation
Ledtischke, Anne
Unknown Affiliation
Finnis, Mackenzie
Unknown Affiliation
Dwivedi, Jyotsna
Unknown Affiliation
Saxena, Manoj K.
Unknown Affiliation
Biradar, Vishwanath
Unknown Affiliation
Soar, Natalie
Unknown Affiliation
Sarode, Vineet V.
Unknown Affiliation
Brewster, David J.
Unknown Affiliation
Regli, Adrian
Unknown Affiliation
Weeda, Elizabeth
Unknown Affiliation
Ahmed, Samiul A.
Unknown Affiliation
Fourie, Cheryl
Unknown Affiliation
Laupland, K. B.
Unknown Affiliation
Ramanan, Mahesh
Unknown Affiliation
Walsham, James
Unknown Affiliation
Meyer, Jason
Unknown Affiliation
Litton, Edward L.
Unknown Affiliation
Palermo, Anne Marie
Unknown Affiliation
Yap, Timothy
Unknown Affiliation
Eroglu, Ege
Unknown Affiliation
Attokaran, Antony George
Unknown Affiliation
Jaramillo, C’havala
Unknown Affiliation
Nafees, Khalid Mahmood Khan
Unknown Affiliation
Rashid, Nurhikmahtul Aqilah Haji Abd
Unknown Affiliation
Walid, Haji Adi Muhamad Ibnu
Unknown Affiliation
Mon, Tomas
Unknown Affiliation
Moorthi, P. Dhakshina
Unknown Affiliation
Sudhirchandra, Shah
Unknown Affiliation
Sridharan, Dhadappa Damodar
Unknown Affiliation
Haibo, Qiu
Unknown Affiliation
Jianfeng, Xie
Unknown Affiliation
Wei-Hua, Lu
Unknown Affiliation
Zhen, Wang
Unknown Affiliation
Qian, Chuangyun
Unknown Affiliation
Luo, Jili
Unknown Affiliation
Chen, Xiaomei
Unknown Affiliation
Zhao, Peng
Unknown Affiliation
Wusi, Qiu
Unknown Affiliation
Mingmin, Chen
Unknown Affiliation
Xu, Lei
Unknown Affiliation
Yin, Chengfen
Unknown Affiliation
Wang, Ruilan
Unknown Affiliation
Wang, Jinfeng
Unknown Affiliation
Yin, Yongjie
Unknown Affiliation
Zhang, Min
Unknown Affiliation
Ye, Jilu
Unknown Affiliation
Hu, Chungfang
Unknown Affiliation
Zhou, Suming
Unknown Affiliation
Huang, Min
Unknown Affiliation
Yan, Jing
Unknown Affiliation
Wang, Yan
Unknown Affiliation
Qin, Bingyu
Unknown Affiliation
Ye, Ling
Unknown Affiliation
Weifeng, Xie
Unknown Affiliation
Peije, Li
Unknown Affiliation
Geng, Nan
Unknown Affiliation
Karumai, Toshiyuki
Unknown Affiliation
Yamasaki, Masaki
Unknown Affiliation
Hashimoto, Satoru
Unknown Affiliation
Hosokawa, Koji
Unknown Affiliation
Makino, Jun
Unknown Affiliation
Matsuyoshi, Takeo
Unknown Affiliation
Kuriyama, Akira
Unknown Affiliation
Saito, Hiroki
Unknown Affiliation
Hasan, M. Shahnaz
Unknown Affiliation
Mazlan, Mohd Zulfakar
Unknown Affiliation
Kwa, Andrea Lay Hoon
Unknown Affiliation
Wongsurakıat, Phunsup
Unknown Affiliation
Nadeem, Rashid
Unknown Affiliation
Houfi, Ashraf El
Unknown Affiliation
Elhadidy, Amr Elsayed
Unknown Affiliation
Osman, Nermin A.
Unknown Affiliation
Mostafa, Tarek Ahmed
Unknown Affiliation
Elbahnasawy, Mohamed
Unknown Affiliation
Aldhalia, Amer
Unknown Affiliation
Elmandouh, Omar
Unknown Affiliation
Elsayed, Ahmad Samy
Unknown Affiliation
Elbadawy, Merihan A.
Unknown Affiliation
Awad, Ahmed K.
Unknown Affiliation
Hemead, Hanan M.
Unknown Affiliation
Mahmoodpor, Ata
Unknown Affiliation
Sabetian, Golnar
Unknown Affiliation
Masjedi, Mansoor
Unknown Affiliation
Ahmed, Abdullah Khudhur
Unknown Affiliation
Singer, Pierre P.
Unknown Affiliation
Abilama, Fayez
Unknown Affiliation
Buimsaedah, Ahmad M.
Unknown Affiliation
Gamra, Marwa F.
Unknown Affiliation
Almiqlash, Bushray
Unknown Affiliation
Bouhuwaish, Ahmad
Unknown Affiliation
Abdulwahed, Eman
Unknown Affiliation
Serghini, Issam
Unknown Affiliation
Seddiki, Rachid
Unknown Affiliation
Boukatta, Brahim
Unknown Affiliation
Kanjaâ, Nabil
Unknown Affiliation
Dendane, Tarek
Unknown Affiliation
Zeggwagh, Amine Ali
Unknown Affiliation
Housni, Brahim
Unknown Affiliation
Hachimi, A.
Unknown Affiliation
Ghannam, Abdelilah
Unknown Affiliation
Belkhadir, Zakaria H.
Unknown Affiliation
Ait Hssain, Ali
Unknown Affiliation
Elbuzidi, Abdurrahmaan Suei
Unknown Affiliation
Karic, Edin
Unknown Affiliation
Lancé, Marcus Daniel
Unknown Affiliation
Sallam, Hend
Unknown Affiliation
Almekhlafi, Ghaleb A.
Unknown Affiliation
AlJabbary, Ahmed S.
Unknown Affiliation
Chaaban, Mohammad Karam
Unknown Affiliation
Bouaziz, Mounir
Unknown Affiliation
Turki, Olfa
Unknown Affiliation
Sellami, Walid
Unknown Affiliation
Fernández, Rubén Oscar
Unknown Affiliation
Reyes, Luis F.
Unknown Affiliation
Ñamendys-Silva, Silvio A.
Unknown Affiliation
Sanchez-Hurtado, Luis A.
Unknown Affiliation
Mesland, Jean Baptiste
Unknown Affiliation
Henin, Pierre Y.
Unknown Affiliation
Haentjens, Lionel L.
Unknown Affiliation
Biston, Patrick
Unknown Affiliation
Misset, Benoıˆt Y.
Unknown Affiliation
Serck, Nicolas
Unknown Affiliation
Wittebole, Xavier
Unknown Affiliation
de Waele, Elisabeth
Unknown Affiliation
Kovačević, Peđa
Unknown Affiliation
Peršec, Jasminka
Unknown Affiliation
Montravers, Philippe
Unknown Affiliation
Auchabie, Johann
Unknown Affiliation
Marchalot, Antoine
Unknown Affiliation
Nica, Alexandru
Unknown Affiliation
Souweine, Bertrand
Unknown Affiliation
Duburcq, Thibault
Unknown Affiliation
Kipnis, Eric
Unknown Affiliation
Mira, Jean Paul
Unknown Affiliation
Garçon, Pierre
Unknown Affiliation
Thyrault, Martial
Unknown Affiliation
Paulet, Rémi
Unknown Affiliation
Philippart, François
Unknown Affiliation
Bruel, Cédric
Unknown Affiliation
Weiss, Emmanuel Hobdy
Unknown Affiliation
Foucrier, Arnaud
Unknown Affiliation
Perrigault, Pierre François O.
Unknown Affiliation
Argaud, Laurent
Unknown Affiliation
Dessap, Armand Mekontsso
Unknown Affiliation
Razazi, Keyvan
Unknown Affiliation
Kalfon, Pierre
Unknown Affiliation
Lefrant, Jean Yves
Unknown Affiliation
Roger, Claire
Unknown Affiliation
Siami, Shidasp
Unknown Affiliation
Fartoukh, Muriel Sarah
Unknown Affiliation
Petros, Sirak
Unknown Affiliation
Wempe, Carola
Unknown Affiliation
Viderman, Dmitriy
Unknown Affiliation
Kaligozhin, Zhannur
Unknown Affiliation
Kaimakamis, Evangelos
Unknown Affiliation
Karaiskos, Ilias
Unknown Affiliation
Dimopoulos, George T.
Unknown Affiliation
Montrucchio, G.
Unknown Affiliation
De Pascale, Gennaro D.
Unknown Affiliation
Montini, Luca Maria
Unknown Affiliation
Carelli, Simone
Unknown Affiliation
Giacobbe, Daniele Roberto
Unknown Affiliation
Zuccaro, Francesco
Unknown Affiliation
Pelosi, Paolo P.
Unknown Affiliation
Battaglini, Denise
Unknown Affiliation
Cortegiani, Andrea
Unknown Affiliation
Ippolito, Mariachiara
Unknown Affiliation
Rocco, Monica
Unknown Affiliation
Tamowicz, Barbara
Unknown Affiliation
Martín-Loeches, Ignacio
Unknown Affiliation
Grinţescu, Ioana Marina
Unknown Affiliation
Filipescu, Daniela C.
Unknown Affiliation
Tomescu, Dana Rodica
Unknown Affiliation
Grigoras, Ioana
Unknown Affiliation
Gritsan, Alexey I.
Unknown Affiliation
Zubareva, Nadezhda A.
Unknown Affiliation
Belskiy, Vladislav A.
Unknown Affiliation
Quesada, María Dolores
Unknown Affiliation
Gomà, Gemma
Unknown Affiliation
Maseda, Emilio
Unknown Affiliation
Gallego, Alberto Orejas
Unknown Affiliation
Sjövall, Fredrik
Unknown Affiliation
Jakob, Stephan Mathias
Unknown Affiliation
Kocagöz, Sesin
Unknown Affiliation
Kuşoğlu, Hülya
Unknown Affiliation
Kayaaslan, Bircan Ünal
Unknown Affiliation
Kaya-Kalem, Ayşe
Unknown Affiliation
Demiray, Emine Kübra Dindar
Unknown Affiliation
Gündoǧan, Kürşat
Unknown Affiliation
Aǧalar, Canan
Unknown Affiliation
Yilmaz, Mesut
Unknown Affiliation
Çakmak, Rumeysa
Unknown Affiliation
Saltoǧlu, Neşe
Unknown Affiliation
Karaali, Rıtvan
Unknown Affiliation
Saraçoǧlu, Kemal Tolga
Unknown Affiliation
Ersöz, Gülden Munis
Unknown Affiliation
Bayındır, Yaşar
Unknown Affiliation
Batırel, Ayşe
Unknown Affiliation
Routledge, Matthew
Unknown Affiliation
Ercole, Ari
Unknown Affiliation
Faulkner, Maria
Unknown Affiliation
Raj, Ashok Sundai
Unknown Affiliation
Torlinski, Tomasz
Unknown Affiliation
Roshdy, Ashraf
Unknown Affiliation
Szakmany, Tamas
Unknown Affiliation
Tatham, Kate Colette
Unknown Affiliation
Jhanji, Shaman
Unknown Affiliation
McGuigan, Peter J.
Unknown Affiliation
Kannan, Santhanagopalan G.
Unknown Affiliation
Chikungwa, Moses T.
Unknown Affiliation
Sligl, Wendy Irene
Unknown Affiliation
Baig, Nadia
Unknown Affiliation
McCoshen, Lorena
Unknown Affiliation
Kutsogiannis, Demetrios James
Unknown Affiliation
Baronia, Arvind Kumar
Unknown Affiliation
Ozair, Ahmad
Unknown Affiliation
Datta, Avijatri
Unknown Affiliation
Patel, Mayur Harshadrai
Unknown Affiliation
Yakubu, Saidu Yusuf
Unknown Affiliation
Olatosi, John Olutola
Unknown Affiliation
Desalu, I.
Unknown Affiliation
Asiyanbi, G. K.
Unknown Affiliation
Idowu, Olusola Kayode
Unknown Affiliation
Adeola, Fowotade
Unknown Affiliation
Hamid, Hytham K.S.
Unknown Affiliation
Statistics
Citations: 47
Authors: 257
Affiliations: 35
Identifiers
Doi:
10.1007/s00134-022-06944-2
ISSN:
03424642
Research Areas
Health System And Policy
Study Design
Cohort Study
Study Approach
Quantitative