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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Failure of a new antivenom to treat Echis ocellatus snake bite in rural Ghana: the importance of quality surveillance
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 102, No. 5, Year 2008
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Description
This study compares two antivenoms used to treat Echis ocellatus snake bite patients at Mathias Hospital, Yeji, central Ghana. FAV-Afrique™ antivenom (Aventis Pasteur) was given to 278 patients during 2001-2003, whilst Asna Antivenom C (Bharat Serum and Vaccines Ltd) was used in 2004 to treat 66 patients. The two groups had comparable patient attributes, time from snake bite to treatment and staff adherence to the tested treatment protocol. The antivenom C group required more repeat doses and twice the amount of antivenom to treat coagulopathy. Of greater concern, the antivenom C mortality rate was 12.1%, a marked rise from the 1.8% rate in the earlier FAV-Afrique™ antivenom group. In this study, antivenom C was ineffective as treatment for West African E. ocellatus snake venom. This illustrates the absolute need for regional pilot tests to assess the effectiveness of a new antivenom against local snake venoms before its sole and general distribution in a region is initiated. © 2007 Royal Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Visser, Lucia E.
Ghana
Mathias Hospital
Kyei-Faried, Sardick
Ghana, Washington, D.c.
Regional Health Directorate
Belcher, D. W.
Ghana, Accra
University of Ghana
Geelhoed, Diederike W.
Unknown Affiliation
Schagen Van Leeuwen, Jules H.
Netherlands, Nieuwegein
St. Antonius Ziekenhuis
van Roosmalen, Jos J.M.
Netherlands, Leiden
Leids Universitair Medisch Centrum
Netherlands, Amsterdam
Vrije Universiteit Amsterdam
Statistics
Citations: 121
Authors: 6
Affiliations: 6
Identifiers
Doi:
10.1016/j.trstmh.2007.11.006
ISSN:
00359203
Research Areas
Health System And Policy
Study Locations
Ghana