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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Impact of smoking on outcomes of patients with a history of recurrent nonmuscle invasive bladder cancer
Journal of Urology, Volume 188, No. 6, Year 2012
Notification
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Description
Purpose: We investigated the effects of cigarette smoking status, cumulative exposure and time from cessation on disease recurrence and progression in patients with a history of recurrent nonmuscle invasive bladder cancer. Materials and Methods: A total of 390 patients with recurrent nonmuscle invasive bladder cancer were treated with transurethral resection of the bladder, of whom 159 (41%) received instillation therapy immediately postoperatively and 73 (19%) received adjuvant intravesical immunotherapy or chemotherapy. Smoking history included smoking status, number of cigarettes per day, smoking duration in years and years since smoking cessation. Cumulative smoking exposure was categorized as light short-term - 19 or fewer cigarettes per day and 19.9 years or less, moderate - all combinations except light short-term and heavy long-term, and heavy long-term - 20 or greater cigarettes per day and 20 years or greater. Results: A total of 91 (23%), 192 (49%) and 107 patients (28%) were never, former and current smokers, respectively. Of ever smokers 56 (19%), 156 (52%) and 87 (29%) were light short-term, moderate and heavy long-term smokers, respectively. There was no difference in the risk of disease recurrence and progression among current, former and never smokers. On univariable analyses in ever smokers the risk of disease recurrence and progression increased with augmented smoking intensity (p ≤0.015), duration (p <0.001) and cumulative exposure (p <0.001). On multivariable analyses cumulative smoking exposure was an independent risk factor for disease recurrence and progression (p ≤0.003). Smoking cessation greater than 10 years before treatment was independently associated with decreased disease recurrence compared to current smoking (HR 0.4, p <0.001). In addition, current smokers had worse survival than former smokers, who in turn had worse survival than never smokers (p >0.05). Conclusions: There is a dose-response relationship of smoking exposure and smoking cessation with disease recurrence and progression in ever smokers with a history of recurrent nonmuscle invasive bladder cancer. These findings support counseling on smoking cessation benefits. © 2012 American Urological Association Education and Research, Inc.
Authors & Co-Authors
Rink, Michael
United States, Ithaca
Cornell University
Germany, Hamburg
Universitätsklinikum Hamburg-eppendorf
Xylinas, Évanguelos N.
United States, Ithaca
Cornell University
France, Paris
Hopital Cochin Ap-hp
Babjuk, Marek M.
Czech Republic, Prague
Fakultní Nemocnice V Motole
Hansen, Jens
Germany, Hamburg
Universitätsklinikum Hamburg-eppendorf
Pycha, Armin
Italy, Bolzano
Regional Hospital of Bolzano
Comploj, Evi
Italy, Bolzano
Regional Hospital of Bolzano
Lotan, Yair R.
United States, Richardson
The University of Texas at Dallas
Sun, Maxine
Canada, Montreal
University of Montreal
I. Karakiewicz, Pierre I.
Canada, Montreal
University of Montreal
Abdennabi, Joual
Morocco, Casablanca
Centre Hospitalier Universitaire Ibn Rochd
Fajkovic, Harun
Austria
General Hospital St. Poelten
Loidl, Wolfgang
Austria, Linz
St. Vincent's Hospital
Chun, Felix K.H.
Germany, Hamburg
Universitätsklinikum Hamburg-eppendorf
Fisch, Margit M.
Germany, Hamburg
Universitätsklinikum Hamburg-eppendorf
Scherr, Douglas S.
United States, Ithaca
Cornell University
Shariat, Shahrokh F.
United States, Ithaca
Cornell University
United States, New York
New York Presbyterian Hospital
Statistics
Citations: 51
Authors: 16
Affiliations: 11
Identifiers
Doi:
10.1016/j.juro.2012.08.029
ISSN:
00225347
e-ISSN:
15273792
Research Areas
Cancer
Substance Abuse