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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Molecular characterization of Panton-Valentine leukocidin-positive community-acquired methicillin-resistant Staphylococcus aureus isolates in Egypt
Microbiological Research, Volume 165, No. 2, Year 2010
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Description
Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) expressing Panton-Valentine leukocidin (PVL) have been characterized worldwide, but it has not been done in Egypt. In this study, we analyzed the molecular characteristics of PVL+CA-MRSA in Egypt, compared their genetic patterns with that of PVL+ methicillin-susceptible S. aureus and PVL+CA-MRSA from different countries, and investigated the allelic variations among their lukS-PV and lukF-PV gene sequences. The prevalence of PVL+MRSA was 19.04%. They belonged to different genetic clones with multi-locus sequence types (MLST) 30, 80, and the novel type 1010. ST80 strains showed unique antibiotic resistance profile that was distinguishable from the European ST80 clone: they had no resistance to tetracycline and fusidic acid. Two nonsynonymous substitutions in the lukS-PV gene region and two haplotype variants among these isolates were detected. We revealed that PVL is a good marker for CA-MRSA infections and that PVL+ isolates belonged to different genotypes. © 2009 Elsevier GmbH. All rights reserved.
Authors & Co-Authors
Enany, Shymaa
Egypt, Ismailia
Faculty of Pharmacy
Japan, Niigata
Niigata University, Graduate School of Medical and Dental Science
Yaoita, Eishin
Japan, Niigata
Niigata University, Graduate School of Medical and Dental Science
Yoshida, Yutaka
Japan, Niigata
Niigata University, Graduate School of Medical and Dental Science
Enany, Mohamed Elsayed
Egypt, Ismailia
Faculty of Veterinary Medicine
Yamamoto, Tadashi
Japan, Niigata
Niigata University, Graduate School of Medical and Dental Science
Statistics
Citations: 58
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1016/j.micres.2009.03.005
ISSN:
09445013
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study
Study Locations
Egypt