Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
A Cathepsin D-Cleaved 16 kDa Form of Prolactin Mediates Postpartum Cardiomyopathy
Cell, Volume 128, No. 3, Year 2007
Notification
URL copied to clipboard!
Description
Postpartum cardiomyopathy (PPCM) is a disease of unknown etiology and exposes women to high risk of mortality after delivery. Here, we show that female mice with a cardiomyocyte-specific deletion of stat3 develop PPCM. In these mice, cardiac cathepsin D (CD) expression and activity is enhanced and associated with the generation of a cleaved antiangiogenic and proapoptotic 16 kDa form of the nursing hormone prolactin. Treatment with bromocriptine, an inhibitior of prolactin secretion, prevents the development of PPCM, whereas forced myocardial generation of 16 kDa prolactin impairs the cardiac capillary network and function, thereby recapitulating the cardiac phenotype of PPCM. Myocardial STAT3 protein levels are reduced and serum levels of activated CD and 16 kDa prolactin are elevated in PPCM patients. Thus, a biologically active derivative of the pregnancy hormone prolactin mediates PPCM, implying that inhibition of prolactin release may represent a novel therapeutic strategy for PPCM. © 2007 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Hilfiker-Kleiner, Denise
Germany, Hannover
Hannover Medical School
Kamiński, Karol Adam
Germany, Hannover
Hannover Medical School
Podewski, Edith Katharina
Germany, Hannover
Hannover Medical School
Bonda, Tomasz
Germany, Hannover
Hannover Medical School
Schaefer, Arnd
Germany, Hannover
Hannover Medical School
Sliwa, Karen S.
South Africa, Johannesburg
Chris Hani Baragwanath Hospital
Förster, Olaf
South Africa, Johannesburg
Chris Hani Baragwanath Hospital
Quint, Anja
Germany, Hannover
Hannover Medical School
Landmesser, Ulf E.
Germany, Hannover
Hannover Medical School
Doerries, Carola
Germany, Hannover
Hannover Medical School
Luchtefeld, Maren
Germany, Hannover
Hannover Medical School
Poli, Valeria
Italy, Turin
Università Degli Studi Di Torino
Schneider, Michael D.
United States, Houston
Baylor College of Medicine
Balligand, Jean Luc
Belgium, Louvain-la-neuve
Faculté de Médecine et Médecine Dentaire
Desjardins, Fanny
Belgium, Louvain-la-neuve
Faculté de Médecine et Médecine Dentaire
Ansari, Aftab Ab A.
United States, Atlanta
Emory University
Struman, Ingrid
Belgium, Liege
Université de Liège
Nguyen, Ngoc Q.N.
Belgium, Liege
Université de Liège
Zschemisch, Nils H.
Germany, Hannover
Hannover Medical School
Klein, Gunnar
Germany, Hannover
Hannover Medical School
Heusch, Gerd
Germany, Essen
Universitätsklinikum Essen
Schulz, Rainer
Germany, Essen
Universitätsklinikum Essen
Hilfiker, Andres
Germany, Hannover
Hannover Medical School
Drexler, Helmut
Germany, Hannover
Hannover Medical School
Statistics
Citations: 794
Authors: 24
Affiliations: 8
Identifiers
Doi:
10.1016/j.cell.2006.12.036
ISSN:
00928674
Research Areas
Maternal And Child Health
Noncommunicable Diseases
Sexual And Reproductive Health
Participants Gender
Female