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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Systemic lupus erythematosus in the elderly
Rheumatology International, Volume 32, No. 5, Year 2012
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Description
Onset of the disease above the age of 65 years is unusual. This study was undertaken to determine retrospectively the clinical and laboratory features in SLE patients aged over 65 years. It is a retrospective study about 18 elderly patients with SLE out of 342 diagnosed between 1994 and 2009 in the center of Tunisia. All patients had at least 4 of 11 revised ACR criteria of SLE. The frequency of SLE in the elderly was 5.3%. The median age was 70 years (range 66 and 78 years). The sex ratio F/M was 5. The most frequent clinical signs were anemia (83.3%), arthralgia (55.5%), arthritis (38.9%), and malar rash (33.3%). The proteinuria and the neuropsychiatric troubles were present in 27.8% of cases. The pericarditis was present in 16.7% of cases. Antibodies to double stranded DNA (anti-dsDNA) were detected in 66.7%, anti-nucleosome in 50%, anti-SSA and anti-RNP in 27.8%, anti-Sm in 22%, and anti-SSB in 11%. Elderly patients with SLE exhibit distinct clinical and biological manifestations from the classic form. Thus, greater attention should be given for this particular subgroup of SLE patients to avoid delays in diagnosis or misdiagnosis. © 2011 Springer-Verlag.
Authors & Co-Authors
Achour, Achouak
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Mankaï, Amani
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Thabet, Yosra
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Sakly, Wahiba
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Braham, Fehmi
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Laouani-Kechrid, Chédia
Tunisia, Sousse
Chu Sahloul
Bahri, Fethi
Tunisia, Sousse
Hopital Farhat Hached Sousse
Bouajina, Elyès
Tunisia, Sousse
Hopital Farhat Hached Sousse
Saoussen, Chouchene
Tunisia, Sousse
Hopital Farhat Hached Sousse
Haddad, Ons
Tunisia, Sousse
Hopital Farhat Hached Sousse
Ghédira, Ibtissem
Tunisia, Sousse
Hopital Farhat Hached Sousse
Statistics
Citations: 18
Authors: 11
Affiliations: 3
Identifiers
Doi:
10.1007/s00296-010-1744-3
ISSN:
01728172
e-ISSN:
1437160X
Research Areas
Genetics And Genomics
Study Design
Cohort Study
Study Locations
Tunisia