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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Ethnic differences in the renal sodium-dopamine relationship: a possible explanation for regional variation in the prevalence of hypertension?
European Journal of Clinical Pharmacology, Volume 37, No. 6, Year 1989
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Description
Twenty-four-h urinary sodium and dopamine output by normotensive adults from 5 different ethnic groups have been measured. The groups differed substantially in the correlation between the urinary output ot sodium and dopamine. Those with a traditionally salt rich diet (Thais, Caucasians, Zimbabweans) showed a strong positive correlation (p<0.001), whereas no such relationship was found in West Africans and Iranians, who come from traditionally salt scarce environments. It is hypothesised that in some races the lack of or uncoupling of the renal sodium-dopamine relationship, possibly as a mechanism to help conserve dietary sodium, predisposes to the development of hypertension when the individuals encounter a salt rich diet. © 1989 Springer-Verlag.
Authors & Co-Authors
Critchley, J. A.J.H.
Hong Kong
Prince of Wales Hospital Hong Kong
Lee, M. R.
United Kingdom, Edinburgh
Royal Infirmary of Edinburgh
Gordon, C. J.
United Kingdom, Edinburgh
Royal Infirmary of Edinburgh
Makarananda, Kittima
Thailand, Nakhon Pathom
Mahidol University
Sriwatanakul, K.
Thailand, Nakhon Pathom
Mahidol University
Balali-Mood, M.
Iran, Mashhad
Imam Reza Hospital
Boye, G. L.
Ghana, Accra
University of Ghana
Statistics
Citations: 7
Authors: 7
Affiliations: 5
Identifiers
Doi:
10.1007/BF00562544
e-ISSN:
14321041
Research Areas
Noncommunicable Diseases
Study Design
Cross Sectional Study