Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells
Science, Volume 347, No. 6225, Year 2015
Notification
URL copied to clipboard!
Description
Although it is generally accepted that cellular differentiation requires changes to transcriptional networks, dynamic regulation of promoters and enhancers at specific sets of genes has not been previously studied en masse. Exploiting the fact that active promoters and enhancers are transcribed, we simultaneously measured their activity in 19 human and 14 mouse time courses covering a wide range of cell types and biological stimuli. Enhancer RNAs, then messenger RNAs encoding transcription factors, dominated the earliest responses. Binding sites for key lineage transcription factors were simultaneously overrepresented in enhancers and promoters active in each cellular system. Our data support a highly generalizable model in which enhancer transcription is the earliest event in successive waves of transcriptional change during cellular differentiation or activation. © 2015, American Association for the Advancement of Science. All rights reserved.
Authors & Co-Authors
Arner, Erik
Unknown Affiliation
Daub, Carsten Olivier
Unknown Affiliation
Andersson, Robin
Unknown Affiliation
Lilje, Berit
Unknown Affiliation
Drabløs, Finn
Unknown Affiliation
Lennartsson, Andreas
Unknown Affiliation
Vitezic, Morana
Unknown Affiliation
Freeman, Tom C.
Unknown Affiliation
Alhendi, Ahmad M.N.
Unknown Affiliation
Arner, Peter
Unknown Affiliation
Axton, Richard A.
Unknown Affiliation
Baillie, J. Kenneth
Unknown Affiliation
Beckhouse, Anthony G.
Unknown Affiliation
Bodega, Beatrice
Unknown Affiliation
Briggs, James Alexander
Unknown Affiliation
Brombacher, Frank
Unknown Affiliation
Detmar, Michael J.
Unknown Affiliation
Ehrlund, Anna
Unknown Affiliation
Endoh, Mitsuhiro
Unknown Affiliation
Eslami, Afsaneh
Unknown Affiliation
Fagiolini, Michela
Unknown Affiliation
Fairbairn, Lynsey
Unknown Affiliation
Faulkner, Geoffrey John
Unknown Affiliation
Ferrai, Carmelo
Unknown Affiliation
Fisher, Malcolm E.
Unknown Affiliation
Forrester, Lesley M.
Unknown Affiliation
Goldowitz, Daniel
Unknown Affiliation
Guler, Reto
Unknown Affiliation
Ha, Thomas J.
Unknown Affiliation
Hara, Mitsuko
Unknown Affiliation
Herlyn, Meenhard M.
Unknown Affiliation
Ikawa, Tomokatsu
Unknown Affiliation
Kai, Chieko
Unknown Affiliation
Kawamoto, Hiroshi
Unknown Affiliation
Khachigian, Levon M.
Unknown Affiliation
Klinken, Svend Peter
Unknown Affiliation
Kojima, Soichi
Unknown Affiliation
Koseki, Haruhiko
Unknown Affiliation
Klein, Sarah
Unknown Affiliation
Mejhert, Niklas
Unknown Affiliation
Mizuno, Yosuke
Unknown Affiliation
Morimoto, Mitsuru
Unknown Affiliation
Morris, Kelly J.
Unknown Affiliation
Nakachi, Yutaka
Unknown Affiliation
Ogishima, Soichi
Unknown Affiliation
Okada, Mariko Hatakeyama
Unknown Affiliation
Okazaki, Yasushi
Unknown Affiliation
Orlando, Valerio
Unknown Affiliation
Passier, Robert C.J.J.
Unknown Affiliation
Pombo, Ana
Unknown Affiliation
Roy, Sugata
Unknown Affiliation
Savvi, Suzana
Unknown Affiliation
Saxena, Alka
Unknown Affiliation
Schwegmann, Anita
Unknown Affiliation
Abugessaisa, Imad
Unknown Affiliation
Bertin, Nicolas
Unknown Affiliation
Diehl, Alexander D.
Unknown Affiliation
Fukuda, Shiro
Unknown Affiliation
Furuno, Masaaki
Unknown Affiliation
Harshbarger, Jayson
Unknown Affiliation
Hasegawa, Akira
Unknown Affiliation
Hori, Fumi
Unknown Affiliation
Kato, Sachi
Unknown Affiliation
Ishizu, Yuri
Unknown Affiliation
Itoh, Masayoshi
Unknown Affiliation
Kawashima, Tsugumi
Unknown Affiliation
Kojima, Miki
Unknown Affiliation
Kondo, Naoto
Unknown Affiliation
Lizio, Marina
Unknown Affiliation
Meehan, Terrence F.
Unknown Affiliation
Mungall, Christopher John
Unknown Affiliation
Murata, Mitsuyoshi
Unknown Affiliation
Nishiyori-Sueki, Hiromi
Unknown Affiliation
Nagao-Sato, Sayaka
Unknown Affiliation
Severin, Jessica M.
Unknown Affiliation
De Hoon, Michiel Jl L.
Unknown Affiliation
Kawai, Jun
Unknown Affiliation
Kasukawa, Takeya
Unknown Affiliation
Lassmann, Timo
Unknown Affiliation
Suzuki, Harukazu
Unknown Affiliation
Kawaji, Hideya
Unknown Affiliation
Summers, Kim M.
Unknown Affiliation
Wells, Christine A.
Unknown Affiliation
Hume, David A.
Unknown Affiliation
Forrest, Alistair R.R.
Unknown Affiliation
Sandelin, Albin
Unknown Affiliation
Carninci, Piero
Unknown Affiliation
Hayashizaki, Yoshihide
Unknown Affiliation
Statistics
Citations: 525
Authors: 88
Identifiers
Doi:
10.1126/science.1259418
ISSN:
00368075