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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Rates of anti-tuberculosis drug resistance in kampala- Uganda are low and not associated with HIV infection
PLoS ONE, Volume 6, No. 1, Article e16130, Year 2011
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Description
Background: Drug resistance among tuberculosis patients in sub-Saharan Africa is increasing, possibly due to association with HIV infection. We studied drug resistance and HIV infection in a representative sample of 533 smear-positive tuberculosis patients diagnosed in Kampala, Uganda. Methods/Principal Findings: Among 473 new patients, multidrug resistance was found in 5 (1.1%, 95% CI 0.3-2.5) and resistance to any drug in 57 (12.1%, 9.3-15.3). Among 60 previously treated patients this was 7 (11.7%, 4.8-22.6) and 17 (28.3%; 17.5-41.4), respectively. Of 517 patients with HIV results, 165 (31.9%, 27.9-36.1) tested positive. Neither multidrug (adjusted odds ratio (ORadj) 0.7; 95% CI 0.19-2.6) nor any resistance (ORadj 0.7; 0.43-1.3) was associated with HIV status. Primary resistance to any drug was more common among patients who had worked in health care (ORadj 3.5; 1.0-12.0). Conclusion/Significance: Anti-tuberculosis drug resistance rates in Kampala are low and not associated with HIV infection, but may be associated with exposure during health care. © 2011 Lukoye et al.
Authors & Co-Authors
Lukoye, Deus
Uganda, Kampala
School of Public Health
Cobelens, Frank G.J.
Netherlands, Amsterdam
Amsterdam Institute for Global Health and Development
Ezati, Nicholas
Unknown Affiliation
Kirimunda, Samuel
Uganda, Kampala
Makerere University School of Public Health
Adatu, Francis E.
Unknown Affiliation
Lule, Joseph Konde
Uganda, Kampala
Makerere University College of Health Sciences
Nuwaha, Fred
Uganda, Kampala
Makerere University College of Health Sciences
Joloba, Moses Lutaakome
Uganda, Kampala
Makerere University School of Public Health
Statistics
Citations: 44
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1371/journal.pone.0016130
e-ISSN:
19326203
Research Areas
Infectious Diseases
Study Design
Case-Control Study
Study Locations
Uganda