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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Igg against plasmodium falciparum variant surface antigens and growth inhibitory antibodies in mozambican children receiving intermittent preventive treatment with sulfadoxine-pyrimethamine
Immunobiology, Volume 216, No. 7, Year 2011
Notification
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Description
This study aimed to evaluate whether intermittent preventive treatment in infants with sulfadoxine-pyrimethamine (IPTi-SP) had an effect on the acquisition of IgG against Plasmodium falciparum variant surface antigens (VSA) and growth-inhibitory antibodies in Manhiça, Mozambique. In addition, we assessed factors affecting the magnitude of these responses and the association between antibody levels and protection against malaria. IgG to VSA expressed by MOZ2, R29 and E8B parasite isolates were measured in plasma samples collected at 5, 9, 12 and 24 months of age by flow cytometry. Growth-inhibitory antibodies in dialyzed plasmas using GFP-D10 parasites were measured by flow cytometry at 12 and 24 months. IPTi-SP did not significantly modify the levels of IgG against VSA nor the growth-inhibitory capacity of antibodies up to 2 years of age. Age but not previous episodes of malaria influenced the magnitude of these responses. In addition, anti-VSA IgG levels were 7% higher in children with current P. falciparum infection and were associated with neighborhood of residence. Children aged 24 months had 10% less parasite growth than those aged 12 months (95% CI 0.88-0.93, P<0.0001). Growth-inhibitory antibodies correlated with levels of IgG against AMA-1, when evaluating the 10% (R2=0.444, P=0.049) and 20% (R2=0.230, P=0.037) highest inhibitory samples. None of the responses were associated with subsequent risk of malaria. In conclusion, IPTi-SP does not negatively affect the development of antibody responses thought to be major contributors to the acquisition of immunity to malaria in infancy. © 2010 Elsevier GmbH.
Authors & Co-Authors
Quelhas, Diana
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Jiménez, Alfons
Spain, Barcelona
Instituto de Salud Global de Barcelona
Quintò, Llorenç L.
Spain, Barcelona
Instituto de Salud Global de Barcelona
Serra-Casas, Elisa
Spain, Barcelona
Instituto de Salud Global de Barcelona
Mayor, A. G.
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Spain, Barcelona
Instituto de Salud Global de Barcelona
Cisteró, Pau
Spain, Barcelona
Instituto de Salud Global de Barcelona
Puyol, Laura
Spain, Barcelona
Instituto de Salud Global de Barcelona
Wilson, Danny W.
Australia, Melbourne
Walter and Eliza Hall Institute of Medical Research
Richards, Jack S.
Australia, Melbourne
Walter and Eliza Hall Institute of Medical Research
Nhampossa, Tacilta
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Mozambique, Maputo
Instituto Nacional de Saude Maputo
MacEte, Eusébio V.
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Aíde, Pedro
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Mozambique, Maputo
Instituto Nacional de Saude Maputo
Mandomando, Inácio M.
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Mozambique, Maputo
Instituto Nacional de Saude Maputo
Sanz, Sergi M.
Spain, Barcelona
Instituto de Salud Global de Barcelona
Aponte, John Jairo
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Mozambique, Maputo
Instituto Nacional de Saude Maputo
Alonso, Pedro Luís
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Mozambique, Maputo
Instituto Nacional de Saude Maputo
Beeson, James G.
Australia, Melbourne
Walter and Eliza Hall Institute of Medical Research
Menéndez, Clara
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Spain, Barcelona
Instituto de Salud Global de Barcelona
Dobaño, Carlota
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Spain, Barcelona
Instituto de Salud Global de Barcelona
Statistics
Citations: 19
Authors: 19
Affiliations: 4
Identifiers
Doi:
10.1016/j.imbio.2010.12.010
ISSN:
01712985
e-ISSN:
18783279
Research Areas
Infectious Diseases
Maternal And Child Health
Study Locations
Mozambique