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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
engineering
Vasculature reconstruction of decellularized liver scaffolds via gelatin-based re-endothelialization
Journal of Biomedical Materials Research - Part A, Volume 107, No. 2, Year 2019
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Description
Decellularized liver scaffolds based liver engineering is a promising approach toward developing functional liver surrogates. However, a major obstacle to long-term transplantation is the hemocompatibility of the bioengineered liver surrogates. One approach to improve the hemocompatibility of engineered liver surrogates is re-endothelialization. In the current study, immortalized endothelial cells were perfused for re-endothelialization of decellularized rat liver scaffolds. When compared to the media-based perfusion approach, gelatin hydrogels-based perfusion significantly increased the number of cells that were retained in the decellularized liver scaffolds and the vascular lumen coverage ratio. Endothelial cells were lining along the vasculatures of the decellularized liver scaffolds and actively proliferating. Re-endothelialization improved the blood retention ability of the liver scaffold vasculatures. Doppler ultrasound detected active blood flows within the re-endothelialized liver scaffold transplants 8 days post-transplantation. Our results strengthened the feasibility of developing bioengineered liver surrogates utilizing decellularized liver scaffolds. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 392–402, 2019.
Authors & Co-Authors
Meng, Fanwei
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Al-Mohanna, Falah Hassan
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Altuhami, Abdullah
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Mohammed Assiri, Abdullah Mohammed
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Saudi Arabia, Riyadh
College of Medicine Alfaisal University
Saudi Arabia, Dammam
Imam Abdulrahman Bin Faisal University
Bröering, Dieter Clemens
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Statistics
Citations: 19
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1002/jbm.a.36551
ISSN:
15493296
e-ISSN:
15524965
Research Areas
Health System And Policy