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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Growth and Morbidity of Gambian Infants are Influenced by Maternal Milk Oligosaccharides and Infant Gut Microbiota
Scientific Reports, Volume 7, Article 40466, Year 2017
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Description
Human milk oligosaccharides (HMOs) play an important role in the health of an infant as substrate for beneficial gut bacteria. Little is known about the effects of HMO composition and its changes on the morbidity and growth outcomes of infants living in areas with high infection rates. Mother's HMO composition and infant gut microbiota from 33 Gambian mother/infant pairs at 4, 16, and 20 weeks postpartum were analyzed for relationships between HMOs, microbiota, and infant morbidity and growth. The data indicate that lacto-N-fucopentaose I was associated with decreased infant morbidity, and 3′-sialyllactose was found to be a good indicator of infant weight-for-age. Because HMOs, gut microbiota, and infant health are interrelated, the relationship between infant health and their microbiome were analyzed. While bifidobacteria were the dominant genus in the infant gut overall, Dialister and Prevotella were negatively correlated with morbidity, and Bacteroides was increased in infants with abnormal calprotectin. Mothers nursing in the wet season (July to October) produced significantly less oligosaccharides compared to those nursing in the dry season (November to June). These results suggest that specific types and structures of HMOs are sensitive to environmental conditions, protective of morbidity, predictive of growth, and correlated with specific microbiota. © The Author(s) 2017.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC5227965/bin/srep40466-s1.pdf
Authors & Co-Authors
Davis, Jasmine C.C.
United States, Davis
University of California, Davis
Bernstein, Robin Miriam
United States, Boulder
University of Colorado Boulder
Moore, Sophie E.
United Kingdom, London
Medical Research Council
United Kingdom, London
London School of Hygiene & Tropical Medicine
Prentice, Andrew M.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Mills, David A.
United States, Davis
University of California, Davis
Lebrilla, Carlito B.
United States, Davis
University of California, Davis
Zivkovic, Angela M.
United States, Davis
University of California, Davis
Statistics
Citations: 142
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1038/srep40466
ISSN:
20452322
Research Areas
Maternal And Child Health