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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Preoperative use of gabapentin decreases the anesthetic and analgesic requirements in patients undergoing radical mastectomy
Egyptian Journal of Anaesthesia, Volume 26, No. 4, Year 2010
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Description
Background/aim: Gabapentin is an anticonvulsant drug that is safe and effective for the treatment of neuropathic pain syndrome, as well as postoperative pain with good results. This prospective randomized study was done to evaluate the effects of preoperative administration of oral gabapentin (1200 mg) on the intraoperative fentanyl and isoflurane consumption, postoperative analgesic requirements and postoperative pain in patients undergoing radical mastectomy. Methods: Sixty ASA I and II patients were randomly allocated into two equal groups to receive oral gabapentin 1200 mg, 2 h before surgery (G group) or control (C group). General anesthesia was induced and maintained at bispectral index value between 40 and 60. During surgery the end-tidal isoflurane concentrations required to maintain adequate depth of anesthesia and the required incremental doses of intraoperative fentanyl were recorded. Postoperative pain was assessed using visual analogue scale (VAS) at rest for 24 h. Postoperatively, whenever visual analogue scale (VAS) was more than 5 or on patients' demand, analgesia in both groups was provided with diclofenac sodium (1 mg/kg IM) or tramadol hydrochloride (1 mg/kg IV) as needed. VAS, analgesics requirements, and side-effects were assessed for 24 h postoperatively. Results: Intraoperative fentanyl and postoperative analgesic consumption were significantly lower in G group than C group (P < 0.001). Patients in the G group had significantly lower end-tidal concentrations of isoflurane required to maintain adequate depth of anesthesia (P < 0.05). VAS was significantly lower in G group than C group at the first three measurement times (P < 0.01). The incidence of postoperative nausea and vomiting was significantly lower in G group than C group (30% versus 60% of patients, respectively, P < 0.05). The incidence of dizziness was significantly higher in the G group than C group (26% versus 3.3% of patients, respectively, P < 0.05). Conclusion: Gabapentin (1200 mg) administered orally 2 h before surgery decreased the intraoperative fentanyl and isoflurane consumption, postoperative analgesic requirements, postoperative pain, and the incidence of postoperative nausea and vomiting, but increased dizziness. © 2010 Egyptian Society of Anesthesiologists. Production and hosting by Elsevier B.V. All rights reserved.
Authors & Co-Authors
Doha, Nagwa M.
Egypt, Shibin el Kom
Menoufia University Hospitals
Rady, Ayman
Egypt, Shibin el Kom
Menoufia University Hospitals
El Azab, Samia R.
Egypt, Cairo
Al-zahraa University Hospital
Egypt
King Fahd Specialist Hospital
Statistics
Citations: 21
Authors: 3
Affiliations: 3
Identifiers
Doi:
10.1016/j.egja.2010.05.004
ISSN:
11101849
e-ISSN:
16871804
Research Areas
Health System And Policy
Study Design
Cohort Study