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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Discordant immunologic and virologic responses to highly active antiretroviral therapy are associated with increased mortality and poor adherence to therapy
Journal of Acquired Immune Deficiency Syndromes, Volume 40, No. 3, Year 2005
Notification
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Description
Objective: To examine the independent association of discordant virologic and immunologic responses to highly active antiretroviral therapy (HAART) with mortality. Methods: A population-based study of 1527 treatment-naive individuals initiating HAART used Cox proportional hazards modeling to determine the independent association of treatment response at 3 to 9 months with nonaccidental mortality. Logistic regression was used to examine associations with discordant responses. Results: Viral load (VL)+/CD4- discordant responses were seen in 235 (15.4%) of subjects, and VL -/CD4+ responses were seen in 179 (11.7%) of subjects. In adjusted Cox regression models, discordant responses were found to be independently associated with an increased risk of mortality (VL +/CD4-: relative hazard [RH] = 1.87, 95% confidence interval [CI]: 1.15 to 3.04; VL-/CD4+: RH = 2.47, 95% CI: 1.54 to 3.95). VL+/CD4- discordance was found to be associated with increasing age, baseline HIV RNA load <100,000 copies/mL, baseline CD4 counts <50 cells/μL, the use of lamivudine (3TC)/zidovudine (ZDV), and poor adherence to therapy. VL-/CD4+ discordance was associated with younger age; injection drug use; baseline HIV RNA load >100,000 copies/mL; the use of 3TC/ZDV, didanosine (ddI)/3TC, or ddl/stavudine; and poor adherence to therapy. Conclusion: Discordant responses are independently associated with an increased risk of mortality and are, in turn, associated with poor adherence to therapy. Copyright © 2005 by Lippincott Williams & Wilkins.
Authors & Co-Authors
Moore, David M.
Canada, Vancouver
British Columbia Centre for Excellence in Hiv-aids
Hogg, Robert S.
Canada, Vancouver
British Columbia Centre for Excellence in Hiv-aids
Canada, Vancouver
The University of British Columbia
Yip, Benita
Canada, Vancouver
British Columbia Centre for Excellence in Hiv-aids
Wood, Evan
Canada, Vancouver
British Columbia Centre for Excellence in Hiv-aids
Canada, Vancouver
The University of British Columbia
Tyndall, Mark W.
Canada, Vancouver
British Columbia Centre for Excellence in Hiv-aids
Canada, Vancouver
The University of British Columbia
Braitstein, Paula K.A.
Canada, Vancouver
British Columbia Centre for Excellence in Hiv-aids
Switzerland, Bern
University of Bern
Montaner, Julio S.G.
Canada, Vancouver
British Columbia Centre for Excellence in Hiv-aids
Canada, Vancouver
The University of British Columbia
Statistics
Citations: 130
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1097/01.qai.0000182847.38098.d1
ISSN:
15254135
Research Areas
Environmental
Infectious Diseases
Study Design
Cross Sectional Study