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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Flavanones from the stem bark of Erythrina abyssinica
Bioorganic and Medicinal Chemistry, Volume 16, No. 24, Year 2008
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Description
Twelve new flavanones bearing a 2,2-dimethylpyrano ring were isolated from a MeOH extract of the stem bark of Erythrina abyssinica. Their structures were determined on the basis of spectroscopic (UV, CD, 1D and 2D NMR, HRMS) and physico-chemical analyses. Compounds 1, 3, 5, 6, 8, and 9 exhibited inhibitory effects on the enzyme activity of PTP1B in an in vitro assay with IC50 values ranging from 13.9 ± 2.1 to 19.0 ± 1.8 μM. These results suggest that prenyl and methoxy groups on the B ring contribute to the inhibitory activity of flavanones against PTP1B. Crown Copyright © 2008.
Authors & Co-Authors
Cui, Long
South Korea, Daejeon
Korea Research Institute of Bioscience and Biotechnology
Thuong, Phuong Thien
South Korea, Gwangju
Chosun University
Lee, Hyun Sun
South Korea, Daejeon
Korea Research Institute of Bioscience and Biotechnology
Tantoh Ndinteh, Derek Tantoh
Cameroon, Yaounde
Université de Yaoundé I
Mbafor, Joseph Tanyi
Cameroon, Yaounde
Université de Yaoundé I
Fomum, Zacharias Tanee
Cameroon, Yaounde
Université de Yaoundé I
Oh, Won Keun
South Korea, Gwangju
Chosun University
Statistics
Citations: 33
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1016/j.bmc.2008.10.012
ISSN:
09680896