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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Comparison of preservative-free ketotifen fumarate and preserved olopatadine hydrochloride eye drops in the treatment of moderate to severe seasonal allergic conjunctivitis
Journal Francais d'Ophtalmologie, Volume 37, No. 1, Year 2014
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Description
Purpose To compare preservative-free ketotifen 0.025% ophthalmic solution to olopatadine 0.1% ophthalmic solution in with the treatment of seasonal allergic conjunctivitis (SAC) in clinical practice. Methods This was a comparative, randomised, investigator-masked, pilot clinical study in adult patients with documented history of SAC and presenting with moderate to severe itching and conjunctival hyperemia. Eligible patients initiated either ketotifen or olopatadine treatment at a dose of one drop twice daily for 28 days. The resolution of ocular signs and symptoms was assessed on day 7 and day 28. Itching was also assessed within 15 minutes following the first instillation (day 0). Conjunctival impression cytology was performed at each visit to assess the evolution of ICAM-1 expression (day 0, 7 and 28). Results Seventy-five patients were randomised (ketotifen: 38 patients; olopatadine: 37 patients). At day 28, the composite score for primary criteria (itching, tearing, and conjunctival hyperemia) improved from 6.8 ± 1.2 to 0.9 ± 1.0 in the Ketotifen group, without statistically significant difference between treatment groups (P = 0.67). There was no relevant difference between treatment groups in other efficacy parameters, except a trend for a more rapid resolution of conjunctival hyperemia in the Ketotifen group. Both drugs were well tolerated, with a trend for a better tolerability reported by patients on ketotifen compared to those on olopatadine at day 7 (P = 0.054). Conclusions A rapid and comparable improvement in SAC was achieved after 28 days of treatment with both preservative-free ketotifen and preserved olopatadine ophthalmic solutions, with a slightly better ocular tolerance with unpreserved ketotifen 0.025% eye drops. © 2013 Elsevier Masson SAS. All rights reserved.
Authors & Co-Authors
Mortemousque, B.
France, Rennes
Hôpital Pontchaillou
Bourcier, Tristan
France, Strasbourg
Hopital Civil
Khairallah, Moncef
Tunisia, Monastir
Chu Fattouma-bourguiba
Messaoud, Riadh
Tunisia
Chu Tahar Sfar
Brignole, Françoise
France, Paris
Faculté Des Sciences Pharmaceutiques et Biologiques
Renault, Didier
France, Clermont-ferrand
Laboratoires Théa
Rebika, H.
France, Clermont-ferrand
Laboratoires Théa
Bremond-Gignac, Dominique
France, Amiens
Chu Amiens Picardie
Statistics
Citations: 15
Authors: 8
Affiliations: 7
Identifiers
Doi:
10.1016/j.jfo.2013.02.007
ISSN:
01815512
Research Areas
Health System And Policy