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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Anticoagulant effects of a Cannabis extract in an obese rat model
Phytomedicine, Volume 14, No. 5, Year 2007
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Description
Blood coagulation studies were conducted to determine the possible anti-/prothrombotic effect of an organic cannabis extract and the three major cannabinoids, THC, CBD and CBN. The in vitro effect of the cannabis extract on thrombin activity produced an IC50 value of 9.89 mg/ml, compared to THC at 1.79 mg/ml. It was also found that the extract, THC and CBN showed considerable inhibition of thrombin-induced clot formation in vitro with IC50 values of 600, 87 and 83 μg/ml for the extract, THC and CBN respectively. In an in vivo model used to determine clotting times of lean and obese rats treated with a cannabis extract, 50% clotting times were found to be 1.5 and 2 fold greater than their respective control groups, supporting the results obtained in the in vitro model. The study thus shows that Cannabis sativa and the cannabinoids, THC and CBN, display anticoagulant activity and may be useful in the treatment of diseases such as type 2 diabetes in which a hypercoagulable state exists. © 2006 Elsevier GmbH. All rights reserved.
Authors & Co-Authors
Coetzee, C.
South Africa, Gqeberha
Nelson Mandela University
Levendal, Ruby Ann
South Africa, Gqeberha
Nelson Mandela University
Van de Venter, Maryna
South Africa, Gqeberha
Nelson Mandela University
Frost, Carminita Lara
South Africa, Gqeberha
Nelson Mandela University
Statistics
Citations: 45
Authors: 4
Affiliations: 1
Identifiers
Doi:
10.1016/j.phymed.2006.02.004
ISSN:
09447113
Research Areas
Noncommunicable Diseases
Substance Abuse