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Structure of Super-Potent Antibody CAP256-VRC26.25 in Complex with HIV-1 Envelope Reveals a Combined Mode of Trimer-Apex Recognition

Cell Reports, Volume 31, No. 1, Article 107488, Year 2020

Antibody CAP256-VRC26.25 is one of the most potent known HIV-1-neutralizing antibodies. Gorman et al. determine the cryo-EM structure of this antibody in complex with the Env trimer that initiated the antibody lineage. The structure reveals how elements of distinct antibody classes can intermingle to yield an antibody of extraordinary potency.

Gorman, Jason
1. United States, Bethesda National Institute of Allergy and Infectious Diseases Niaid
Chuang, Gwoyu
1. United States, Bethesda National Institute of Allergy and Infectious Diseases Niaid
Lai, Yen Ting
1. United States, Bethesda National Institute of Allergy and Infectious Diseases Niaid
Shen, Chen Hsiang
1. United States, Bethesda National Institute of Allergy and Infectious Diseases Niaid
Boyington, Jeffrey C.
1. United States, Bethesda National Institute of Allergy and Infectious Diseases Niaid
Druz, Aliaksandr
1. United States, Bethesda National Institute of Allergy and Infectious Diseases Niaid
Geng, Hui
1. United States, Bethesda National Institute of Allergy and Infectious Diseases Niaid
Louder, Mark K.
1. United States, Bethesda National Institute of Allergy and Infectious Diseases Niaid
McKee, Krisha
1. United States, Bethesda National Institute of Allergy and Infectious Diseases Niaid
Rawi, Reda
1. United States, Bethesda National Institute of Allergy and Infectious Diseases Niaid
Verardi, Raffaello
1. United States, Bethesda National Institute of Allergy and Infectious Diseases Niaid
Yang, Yongping
1. United States, Bethesda National Institute of Allergy and Infectious Diseases Niaid
Zhang, Baoshan
1. United States, Bethesda National Institute of Allergy and Infectious Diseases Niaid
Doria-Rose, Nicole A.
1. United States, Bethesda National Institute of Allergy and Infectious Diseases Niaid
Lin, Bob C.
1. United States, Bethesda National Institute of Allergy and Infectious Diseases Niaid
Moore, Penny L.
1. South Africa, Johannesburg National Institute for Communicable Diseases
2. South Africa, Johannesburg University of the Witwatersrand Faculty of Health Sciences
3. South Africa, Congella Centre for the Aids Programme of Research in South Africa
Morris, Lynn
1. South Africa, Johannesburg National Institute for Communicable Diseases
2. South Africa, Johannesburg University of the Witwatersrand Faculty of Health Sciences
3. South Africa, Congella Centre for the Aids Programme of Research in South Africa
Shapiro, Lawrence S.
1. United States, Bethesda National Institute of Allergy and Infectious Diseases Niaid
2. United States, New York Columbia University
Mascola, John R.
1. United States, Bethesda National Institute of Allergy and Infectious Diseases Niaid
Kwong, Peter D.
1. United States, Bethesda National Institute of Allergy and Infectious Diseases Niaid
2. United States, New York Columbia University

AFRICAN RESEARCH NEXUS

Structure of Super-Potent Antibody CAP256-VRC26.25 in Complex with HIV-1 Envelope Reveals a Combined Mode of Trimer-Apex Recognition

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AFRICAN RESEARCH NEXUS

Structure of Super-Potent Antibody CAP256-VRC26.25 in Complex with HIV-1 Envelope Reveals a Combined Mode of Trimer-Apex Recognition

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African Research Nexus

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