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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Monitoring CD27 expression to evaluate mycobacterium tuberculosis activity in HIV-1 infected individuals in vivo
PLoS ONE, Volume 6, No. 11, Article e27284, Year 2011
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Description
The level of bacterial activity is only poorly defined during asymptomatic Mycobacterium tuberculosis (MTB) infection. The objective was to study the capacity of a new biomarker, the expression of the T cell maturation marker CD27 on MTB-specific CD4 T cells, to identify active tuberculosis (TB) disease in subjects from a MTB and HIV endemic region. The frequency and CD27 expression of circulating MTB-specific CD4 T cells was determined in 96 study participants after stimulation with purified protein derivative (PPD) using intracellular cytokine staining for IFNgamma (IFNγ). Subjects were then stratified by their TB and HIV status. Within PPD responders, a CD27 - phenotype was associated with active TB in HIV - (p = 0.0003) and HIV + (p = 0.057) subjects, respectively. In addition, loss of CD27 expression preceded development of active TB in one HIV seroconverter. Interestingly, in contrast to HIV - subjects, MTB-specific CD4 T cell populations from HIV + TB-asymptomatic subjects were often dominated by CD27 - cells. These data indicate that down-regulation of CD27 on MTB-specific CD4 T cell could be used as a biomarker of active TB, potentially preceding clinical TB disease. Furthermore, these data are consistent with the hypothesis that late, chronic HIV infection is frequently associated with increased mycobacterial activity in vivo. The analysis of T cell maturation and activation markers might thus be a useful tool to monitor TB disease progression. © 2011 Schuetz et al.
Authors & Co-Authors
Schuetz, Alexandra
Tanzania, Mbeya
Referral Hospital
United States, Rockville
Hjf
Haule, Antelmo
Tanzania, Mbeya
Referral Hospital
Reither, Klaus
Tanzania, Mbeya
Referral Hospital
Germany, Munich
Ludwig-maximilians-universität München
Ngwenyama, Njabulo
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Rachow, Andrea
Tanzania, Mbeya
Referral Hospital
Germany, Munich
Ludwig-maximilians-universität München
Meyerhans, Andreas
Germany, Homburg
Universitätsklinikum Des Saarlandes Medizinische Fakultät Der Universität Des Saarlandes
Maboko, Leonard L.
Tanzania, Mbeya
Referral Hospital
Koup, Richard A.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Höelscher, Michael
Germany, Munich
Ludwig-maximilians-universität München
Geldmacher, Christof
Germany, Munich
Ludwig-maximilians-universität München
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Statistics
Citations: 45
Authors: 10
Affiliations: 5
Identifiers
Doi:
10.1371/journal.pone.0027284
e-ISSN:
19326203
Research Areas
Infectious Diseases