Scale-Up of HIV Antiretroviral Therapy and Estimation of Averted Infections and HIV-Related Deaths — Uganda, 2004–2022

What is already known about this topic? In January 2003, the U.S. President’s Emergency Plan for AIDS Relief (PEPFAR) was launched. In April 2004, Uganda became the first country to provide PEPFAR-supported antiretroviral therapy (ART). What is added by this report? During 2004–2022, the number of persons with HIV infection receiving PEPFAR-supported ART increased by nearly 5,000%, to more than 1.3 million, averting nearly 500,000 HIV infections, including more than 230,000 among HIV-exposed infants, and approximately 600,000 HIV-related deaths. What are the implications for public health practice? Going forward, efforts will focus on identifying all persons with HIV infection and linking them to effective ART. PEPFAR remains committed to continued strong partnership with the Government of Uganda and other stakeholders toward ending the global AIDS epidemic by 2030 and safeguarding the long-term impact.