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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Partition of perfluoroalkyl substances (PFASs) in whole blood and plasma, assessed in maternal and umbilical cord samples from inhabitants of arctic Russia and Uzbekistan
Science of the Total Environment, Volume 447, Year 2013
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Description
Perfluoroalkyl substances (PFASs) are ubiquitous in the environment world-wide. Our overall objective was to assess the exposure to PFASs experienced by delivering women and their new-borns in the industrial city of Norilsk (arctic Russia) and the rural Aral Sea region of Uzbekistan, with the secondary objective of evaluating the distribution of PFASs between blood cell and plasma fractions. Six PFASs were detected in every sample from Norilsk city with the plasma concentration sequence of: PFOS>PFOA>PFNA>FOSA>PFHxS>PFUnDA. In the Uzbekistani samples, only PFOS was reported above the MDL (0.08ng/mL). The median plasma concentrations of PFOS of 11.0ng/mL for the Norilsk mothers was comparable to that reported for western countries, while that for Uzbekistan was considerably lower (0.23ng/mL). Apparent increases in the maternal-cord concentration ratios for both whole blood and plasma were evident with the length of the carbon chain for both the carboxylate and the sulfonate PFASs. The median value of this ratio for FOSA in plasma was the lowest, while that for whole blood was the highest. Other than for FOSA, the observed plasma-whole blood concentration ratios for maternal and umbilical cord blood were consistent with a priori calculations using appropriate packed cell and plasma volumes for neonates and pregnant women at term. Clearly FOSA favored whole blood, and acid-base equilibrium calculations suggested that the resonance-stabilized sulfonamidate ion resides in the blood cell fraction. Thus for PFASs and related compounds with pKa values with magnitudes comparable to physiological pH, it is pertinent to measure the cell-associated fraction (separately or as whole blood). Our study illustrates that consideration of both the physico-chemical properties of the contaminants and the physiological attributes of blood matrices were helpful in the interpretation of our findings. © 2013 Elsevier B.V.
Authors & Co-Authors
Hanssen, Linda
Norway, Tromso
Uit Norges Arktiske Universitet
Norway, Skedsmokorset
Norsk Institutt for Luftforskning
Huber, Sandra
Norway, Skedsmokorset
Norsk Institutt for Luftforskning
Odland, Jon Øyvind
Norway, Tromso
Uit Norges Arktiske Universitet
Nieboer, Evert
Norway, Tromso
Uit Norges Arktiske Universitet
Canada, Hamilton
Mcmaster University
Sandanger, Torkjel Manning
Norway, Tromso
Uit Norges Arktiske Universitet
Norway, Skedsmokorset
Norsk Institutt for Luftforskning
Statistics
Citations: 116
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1016/j.scitotenv.2013.01.029
ISSN:
18791026
Research Areas
Environmental
Maternal And Child Health
Participants Gender
Female