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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Serum Metabolome Signatures Characterizing Co-Infection of Plasmodium falciparum and HBV in Pregnant Women
Diseases, Volume 11, No. 3, Article 94, Year 2023
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Description
Plasmodium falciparum (P. falciparum) and hepatitis B virus (HBV) co-infection is on the rise among pregnant women in northern Ghana. Mono-infection with either of these two pathogens results in unique metabolic alterations. Thus, we aimed to explicate the effects of this co-infection on the metabolome signatures of pregnant women, which would indicate the impacted metabolic pathways and provide useful prognostic or diagnostic markers. Using an MS/MS-based targeted metabolomic approach, we determined the serum metabolome in pregnant women with P. falciparum mono-infection, HBV mono-infection, P. falciparum, and HBV co-infection and in uninfected (control) women. We observed significantly decreased sphingolipid concentrations in subjects with P. falciparum mono-infection, whereas amino acids and phospholipids were decreased in subjects with HBV mono-infection. Co-infections were found to be characterized distinctively by reduced concentrations of phospholipids and hexoses (mostly glucose) as well as altered pathways that contribute to redox homeostasis. Overall, PC ae C40:1 was found to be a good discriminatory metabolite for the co-infection group. PC ae C40:1 can further be explored for use in the diagnosis and treatment of malaria and chronic hepatitis B co-morbidity as well as to distinguish co-infections from cases of mono-infections. © 2023 by the authors.
Authors & Co-Authors
Anabire, Nsoh Godwin
Ghana, Accra
University of Ghana
Ghana, Tamale
University for Development Studies Ghana
Bauer, Michael
Germany, Jena
Friedrich-schiller-universität Jena
Weis, Sebastian
Germany, Jena
Friedrich-schiller-universität Jena
Germany, Jena
Leibniz-institut Für Naturstoff-forschung Und Infektionsbiologie E. V. – Hans-knöll-institut
Neugebauer, Sophie
Germany, Jena
Universitätsklinikum Jena Und Medizinische Fakultät
Quaye, Osbourne
Ghana, Accra
University of Ghana
Helegbe, Gideon Kofi
Ghana, Accra
University of Ghana
Ghana, Tamale
University for Development Studies Ghana
Statistics
Authors: 6
Affiliations: 5
Identifiers
Doi:
10.3390/diseases11030094
ISSN:
20799721
Research Areas
Infectious Diseases
Noncommunicable Diseases
Study Locations
Ghana
Participants Gender
Female