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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Inhaled microparticles containing clofazimine are efficacious in treatment of experimental tuberculosis in mice
Antimicrobial Agents and Chemotherapy, Volume 57, No. 2, Year 2013
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Description
Inhalable clofazimine-containing dry powder microparticles (CFM-DPI) and native clofazimine (CFM) were evaluated for activity against Mycobacterium tuberculosis in human monocyte-derived macrophage cultures and in mice infected with a low-dose aerosol. Both formulations resulted in 99% killing at 2.5 g/ml in vitro. In mice, 480 g and 720 g CFM-DPI inhaled twice per week over 4 weeks reduced numbers of CFU in the lung by as much as log10 2.6; 500 g oral CFM achieved a log10 0.7 reduction. Copyright © 2013, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Verma, Rahul Kumar
India, Lucknow
Central Drug Research Institute India
Germishuizen, Willem Andreas
India, Lucknow
Central Drug Research Institute India
South Africa, Centurion
Deltamune Pty Ltd
Motheo, M. Portia
India, Lucknow
Central Drug Research Institute India
Agrawal, Atul Kumar
South Africa, Centurion
Deltamune Pty Ltd
Singh, Amit Kumar
South Africa, Pretoria
University of Pretoria
Mohan, Mradul
India, Agra
National Jalma Institute of Leprosy and Other Mycobacterial Diseases India
Gupta, Pushpa
India, Agra
National Jalma Institute of Leprosy and Other Mycobacterial Diseases India
South Africa, Pretoria
Faculty of Health Sciences
Gupta, Umesh Datta
India, Lucknow
Central Drug Research Institute India
Cholo, Moloko C.
India, Lucknow
Central Drug Research Institute India
Anderson, Ronald
India, Lucknow
Central Drug Research Institute India
Fourie, P. B.
India, Lucknow
Central Drug Research Institute India
Misra, Amit
India, Lucknow
Central Drug Research Institute India
South Africa, Centurion
Deltamune Pty Ltd
South Africa, Pretoria
University of Pretoria
Statistics
Citations: 57
Authors: 12
Affiliations: 5
Identifiers
Doi:
10.1128/AAC.01897-12
ISSN:
00664804
e-ISSN:
10986596
Research Areas
Health System And Policy