Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Viral dynamics and CD4
+
T cell counts in subtype C human immunodeficiency virus type 1-infected individuals from southern Africa
AIDS Research and Human Retroviruses, Volume 21, No. 4, Year 2005
Notification
URL copied to clipboard!
Description
Defining viral dynamics in natural infection is prognostic of disease progression and could prove to be important for vaccine trial design as viremia may be a likely secondary end point in phase III HIV efficacy trials. There are limited data available on the early course of plasma viral load in subtype C HIV-1 infection in Africa. Plasma viral load and CD4+ T cell counts were monitored in 51 recently infected subjects for 9 months. Individuals were recruited from four southern African countries: Zambia, Malawi, Zimbabwe, and South Africa and the median estimated time from seroconversion was 8.9 months (interquartile range, 5.7-14 months). All were infected with subtype C HIV-1 and median viral loads, measured using branched DNA, ranged from 3.82-4.02 log 10 RNA copies/ml from 2-24 months after seroconversion. Viral loads significantly correlated with CD4+ cell counts (r = -0.5, p < 0.0001; range, 376-364 cells/mm3) and mathematical modeling defined a median set point of 4.08 log10 (12 143 RNA copies/ml), which was attained approximately 17 months after seroconversion. Comparative measurements using three different viral load platforms (bDNA, Amplicor, and NucliSens) confirmed that viremia in subtype C HIV-1-infected individuals within the first 2 years of infection did not significantly differ from that found in early subtype B infection. In conclusion, the course of plasma viremia, as described in this study, will allow a useful baseline comparator for understanding disease progression in an African setting and may be useful in the design of HIV-1 vaccine trials in southern Africa. © Mary Ann Liebert, Inc.
Authors & Co-Authors
Gray, Clive M.
South Africa, Johannesburg
National Institute for Communicable Diseases
Williamson, Carolyn
South Africa, Cape Town
University of Cape Town
Bredell, Helba
South Africa, Pretoria
University of Pretoria
Puren, Adrian
South Africa, Johannesburg
National Institute for Communicable Diseases
Xia, Xiaohua
South Africa, Pretoria
University of Pretoria
Filter, R. A.
South Africa, Pretoria
University of Pretoria
Zijenah, Lynn Sodai
Zimbabwe, Harare
University of Zimbabwe
Cao, Huyen L.
United States, Washington, D.c.
United States Department of Health and Human Services
Morris, Lynn
South Africa, Johannesburg
National Institute for Communicable Diseases
Vardas, Eftyhia
South Africa, Tygerberg
South African Medical Research Council
Colvin, Mark S.E.
South Africa, Tygerberg
South African Medical Research Council
Gray, Glenda E.
South Africa, Johannesburg
University of the Witwatersrand
McIntyre, James Alasdair
South Africa, Johannesburg
University of the Witwatersrand
Musonda, Rosemary Mubanga
Zambia, Lusaka
Zambia-uab Hiv Research Project
Allen, Susan A.
Zambia, Lusaka
Zambia-uab Hiv Research Project
Katzenstein, David A.
United States, Stanford
Stanford Healthcare
Mbizo, Mike
Zimbabwe, Harare
University of Zimbabwe
Kumwenda, Newton I.
Malawi
Johns Hopkins Research Project
Taha, Taha E.
Malawi
Johns Hopkins Research Project
Abdool Karim, Salim S.
South Africa, Tygerberg
South African Medical Research Council
Flores, Jorge
United States, Bethesda
National Institutes of Health Nih
Sheppard, Haynes W.
United States, Washington, D.c.
United States Department of Health and Human Services
Statistics
Citations: 32
Authors: 22
Affiliations: 11
Identifiers
Doi:
10.1089/aid.2005.21.285
ISSN:
08892229
Research Areas
Genetics And Genomics
Infectious Diseases
Study Locations
Malawi
South Africa
Zambia
Zimbabwe