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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Within-host viral dynamics of dengue serotype 1 infection
Journal of the Royal Society Interface, Volume 11, No. 96, Article 20140094, Year 2014
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Description
Dengue, the most common mosquito-borne viral infection of humans, is endemic across much of the world, including much of tropical Asia and is increasing in its geographical range. Here, we present a mathematical model of dengue virus dynamics within infected individuals, detailing the interaction between virus and a simple immune response. We fit this model to measurements of plasma viral titre from cases of primary and secondary DENV 1 infection in Vietnam. We show that variation in model parameters governing the immune response is sufficient to create the observed variation in virus dynamics between individuals. Estimating model parameter values, we find parameter differences between primary and secondary cases consistent with the theory of antibody-dependent enhancement (namely enhanced rates of viral entry to target cells in secondary cases). Finally, we use our model to examine the potential impact of an antiviral drug on the within-host dynamics of dengue. We conclude that the impact of antiviral therapy on virus dynamics is likely to be limited if therapy is only started at the onset of symptoms, owing to the typically late stage of viral pathogenesis reached by the time symptoms are manifested and thus treatment is started. © 2014 The Authors.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC4032531/bin/rsif20140094supp1.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC4032531/bin/rsif20140094supp2.xlsx
Authors & Co-Authors
Clapham, Hannah E.
United Kingdom, London
Imperial College London
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Tricou, Vianney
Central African Republic, Bangui
Institut Pasteur de Bangui
van Vinh Chau, Nguyen
United Kingdom, London
University College London Hospitals Nhs Foundation Trust
Simmons, Cameron Paul
Viet Nam, Ho Chi Minh City
Oxford University Clinical Research Unit
United Kingdom, Oxford
Nuffield Department of Medicine
Australia, Melbourne
University of Melbourne
Ferguson, Neil Morris
United Kingdom, London
Imperial College London
Statistics
Citations: 5
Authors: 5
Affiliations: 7
Identifiers
Doi:
10.1098/rsif.2014.0094
ISSN:
17425689
e-ISSN:
17425662
Research Areas
Infectious Diseases