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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Cognitive ability and metabolic physical health in first-episode psychosis
Schizophrenia Research: Cognition, Volume 24, Article 100194, Year 2021
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Description
Cognitive impairments are a core feature of first-episode psychosis (FEP), arising before illness onset and antipsychotic exposure. Individuals with chronic psychosis experience poorer physical health while taking antipsychotic medication, but health disparities may be evident at FEP onset, prior to antipsychotic exposure. Given the links between cognition and physical health in healthy populations, the aim was to explore whether cognition and physical health are associated in FEP, which could inform early physical health interventions for cognition in FEP. Participants were aged 15 to 25 and included 86 individuals experiencing FEP with limited antipsychotic exposure and duration of untreated psychosis of ≤six months, and 43 age- and sex-matched controls. Individuals with FEP performed significantly poorer than controls in most cognitive domains (Cohen's d = 0.38 to 1.59). Groups were similar in metabolic health measures, excluding a significantly faster heart rate in FEP (d = 0.68). Through hierarchical regression analyses, we found that in the overall sample, BMI was negatively related to current IQ after controlling for education and group (FEP/control). Relationships between BMI and cognition were consistent across the FEP and healthy control groups. In FEP, current IQ and working memory were negatively correlated with lipid profiles. Findings suggest that in FEP, impaired cognition is exhibited earlier than physical health problems, and that compared to controls, similar relationships with cognition are demonstrated. Causal pathways and trajectories of relationships between health and cognition in FEP require investigation, especially as antipsychotic medications are introduced. The findings have implications for cognitive and health interventions. © 2021 The Author(s)
Authors & Co-Authors
O'Donoghue, Brian
Australia, Melbourne
Orygen Youth Health
Australia, Melbourne
University of Melbourne
Hester, Robert L.
Australia, Melbourne
University of Melbourne
Nelson, Barnaby
Australia, Melbourne
Orygen Youth Health
Australia, Melbourne
University of Melbourne
Fornito, Alex
Australia, Melbourne
University of Melbourne
Australia, Clayton
Monash University
Pantelis, Christos S.
Australia, Melbourne
University of Melbourne
Australia, Melbourne
The Florey
Thompson, Andrew D.
Australia, Melbourne
Orygen Youth Health
Australia, Melbourne
University of Melbourne
Berk, Michael
Australia, Melbourne
Orygen Youth Health
Australia, Melbourne
University of Melbourne
Australia, Geelong
Deakin University
McGorry, Patrick D.
Australia, Melbourne
Orygen Youth Health
Australia, Melbourne
University of Melbourne
Statistics
Citations: 5
Authors: 8
Affiliations: 6
Identifiers
Doi:
10.1016/j.scog.2021.100194
ISSN:
22150013
Research Areas
Noncommunicable Diseases