Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
New cholinesterase-inhibiting triterpenoid alkaloids from Buxus hyrcana
Chemistry and Biodiversity, Volume 3, No. 9, Year 2006
Notification
URL copied to clipboard!
Description
The current phytochemical investigation on Buxus hyrcana POJARK. has resulted in the isolation of the triterpenoid alkaloids 1-10. The structures of five new alkaloids, hyrcanone (1), hyrcanol (2), hyrcatrienine (3), Nb-dimethylcycloxobuxoviricine (4), and hyrcamine (5), were elucidated by means of modern spectroscopic techniques, while the known alkaloids, buxidin (6), buxandrine (7), buxabenzacinine (8), buxippine-K (9) and E-buxenone (10), were identified by comparing their spectral data with those reported earlier. Compounds 1 and 3-9 were found to be acetyl- and butyrylcholinesterase inhibitors. The IC50 values were estimated to be in the range of 83.0-468.0 μM against AChE and 1.12-350.0 μM against BChE. The structure-activity relationship studies suggested that the presence of dimethylamino moieties at C(3) and C(20) is the most important factor influencing the activity of these compounds against the cholinesterase enzymes. All compounds were also evaluated for cytotoxicity on a fibroblast cell line with incubation of 24 h. No cytotoxic effects were exerted by any compound. © 2006 Verlag Helvetica Chimica Acta AG, Zürich.
Authors & Co-Authors
Choudhary, Mohammed Iqbal
Pakistan, Karachi
University of Karachi
Shahnaz, Salma
Pakistan, Karachi
University of Karachi
Khalid, Asaad
Pakistan, Karachi
University of Karachi
Mesaik, M. Ahmed
Pakistan, Karachi
University of Karachi
Ayatollahi, Seyed Abdulmajid
Iran, Tehran
Sbums School of Pharmacy
Rahman, Atta Ur
Pakistan, Karachi
University of Karachi
Statistics
Citations: 41
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1002/cbdv.200690102
ISSN:
16121880