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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Interleukin-32 expression is associated with a poorer prognosis in head and neck squamous cell carcinoma
Molecular Carcinogenesis, Volume 53, No. 8, Year 2014
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Description
Head and neck squamous cell carcinoma (HNSCC) represent the sixth most common malignancy diagnosed worldwide. Patient's survival is low due the high frequency of tumor recurrence. Inflammation promotes carcinogenesis as well as the formation of metastasis. Indeed, proinflammatory mediators are known to stimulate the expression of specific transcription factors such as Snai1 and to increase the ability of tumor cells to migrate into distant organs. The atypical interleukin-32 (IL32) was mainly described to exacerbate inflammatory responses in rheumatoid arthritis and inflammatory bowel diseases. IL32 is expressed in various cancers but its role in HNSCC physiology is still unexplored. Here, we analyzed the expression of IL32 and its implication on HNSCC aggressiveness. We showed that patients with tumor expressing high amounts of IL32 exhibit decreased disease-free periods (20.5mo vs. 41mo, P=0.0041) and overall survival (P=0.0359) in comparison with individuals with weak IL32 tumor expression. This overexpression was negatively correlated with gender (P=0.0292) and p53 expression (P=0.0307). In addition, in vitro data linked IL32 expression to metastasis formation since IL32 inhibition decreased Snai1 expression and tumor cell migration in a Boyden chamber assay. Our data provide new insight into the role of IL32 in HNSCC aggressiveness. © 2013 Wiley Periodicals, Inc.
Authors & Co-Authors
Guenin, Samuel
Belgium, Liege
Université de Liège
Mouallif, Mustapha
Belgium, Liege
Université de Liège
Morocco, Casablanca
Hassan Ii University of Casablanca
Hubert, Pascale M.
Belgium, Liege
Université de Liège
Jacobs, Nathalie
Belgium, Liege
Université de Liège
Krusy, Nathalie
Belgium, Liege
Université de Liège
Duray, Anaëlle
Belgium, Mons
Université de Mons
Ennaji, M. M.
Morocco, Casablanca
Hassan Ii University of Casablanca
Saussez, Sven
Belgium, Mons
Université de Mons
Delvenne, Philippe O.
Belgium, Liege
Université de Liège
Statistics
Citations: 18
Authors: 9
Affiliations: 3
Identifiers
Doi:
10.1002/mc.21996
ISSN:
08991987
e-ISSN:
10982744
Research Areas
Cancer
Health System And Policy