Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Genetic diversity of HIV-1 in western Kenya: Subtype-specific differences in mother-to-child transmission
AIDS, Volume 17, No. 11, Year 2003
Notification
URL copied to clipboard!
Description
Background: Little is known about the impact of HIV-1 group M subtypes on mother-to-child transmission (MTCT) of HIV-1 in African settings where multiple HIV-1 group M subtypes are co-circulating. Objective: To assess the role of subtype variation on MTCT. Methods: HIV-1-infected women attending an antenatal clinic in western Kenya were enrolled for a prospective study (1996-2000) of MTCT. HIV-1 subtype analysis of p24gag and gp41env identified potential recombinants, and their role in MTCT was determined. Results: Among 414 women for whom HIV-1 subtype and HIV transmission status were available, MTCT occurred in 80 (19.3%). MTCT rates were higher among women with subtype D compared with subtype A in either the gp41 region [31.6 versus 16.1%, relative risk (RR) 2.0, P = 0.002] or p24 region (29.9 versus 18.0%, RR 1.7, P = 0.02). Discordant subtype combinations were identified in 103 of the women (25.9%), and were associated with higher rates of MTCT (28.2 versus 17.0%, RR 1.7, P = 0.01). In multivariate analysis, women with subtype combinations D/D, D/A, and A/D had an increased risk of MTCT (adjusted odds ratios 3.5, 2.5, 6.2; P = 0.005, 0.05, and 0.0003, respectively) compared with A/A women after adjustment for maternal HIV viral load, placental malaria infection, episiotomy or perineal tear, and low birthweight. Conclusion: MTCT appears to be more common among mothers infected with subtype D compared with subtype A. Such differences in MTCT frequency may be caused by altered cellular tropism for placental cell types. © 2003 Lippincott Williams & Wilkins.
Authors & Co-Authors
Yang, Chunfu
United States, Atlanta
Centers for Disease Control and Prevention
Li, Ming
United States, Atlanta
Centers for Disease Control and Prevention
Newman, Robert David
United States, Atlanta
National Center for Infectious Diseases
United States, Atlanta
Centers for Disease Control and Prevention
Shi, Yaping
United States, Atlanta
National Center for Infectious Diseases
Kenya, Nairobi
Kenya Medical Research Institute
Ayisi, John G.
Kenya, Nairobi
Kenya Medical Research Institute
van Eijk, Anna Maria
Kenya, Nairobi
Kenya Medical Research Institute
Otieno, Juliana A.
Kenya, Kisumu
New Nyanza Provincial General Hospital
Misore, Ambrose O.
Kenya, Kisumu
New Nyanza Provincial General Hospital
Steketee, Richard W.
United States, Atlanta
National Center for Infectious Diseases
Nahlen, Bernard L.
United States, Atlanta
National Center for Infectious Diseases
Switzerland, Geneva
Organisation Mondiale de la Santé
Lal, Renu B.
United States, Atlanta
Centers for Disease Control and Prevention
United States, Atlanta
Dastlr
Statistics
Citations: 81
Authors: 11
Affiliations: 6
Identifiers
Doi:
10.1097/00002030-200307250-00011
Research Areas
Genetics And Genomics
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study
Study Locations
Kenya
Participants Gender
Female